Figure 2.

Microarray analysis of the testis transcriptomes of the three MSYq deficient models. (a) Scatter plots showing transcription levels for the testis transcripts of MSYq deficient models relative to their controls. Expression in the MSYq deficient mice (y-axis, Cy3 label, arbitrary units) for each clone is plotted versus expression in age- and strain-matched normal testis control (x-axis, Cy5 label, arbitrary units). Data from four technical replicates are combined. Data are normalized on the median signal for each channel and then filtered (as described in Materials and methods) to show only clones with data for two technical replicates from each model. The data points showing significant reduction are plotted as enlarged triangles (Y clones green or red, and one X clone black - for clone identities see b). (b) The 23 cDNA clones identifying transcripts that were significantly reduced in one or more of the MSYq deficient models. The clones deriving from the two Y families and the one X family are color coded.