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The design of transcription-factor binding sites is affected by combinatorial regulation

Yonatan Bilu1 and Naama Barkai12*

Author Affiliations

1 Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel

2 Department of Physics of Complex Systems, Weizmann Institute of Science, 76100 Rehovot, Israel

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Genome Biology 2005, 6:R103  doi:10.1186/gb-2005-6-12-r103

Published: 2 December 2005

Additional files

Additional data file 1:

A figure depicting the effective length and fuzziness of motifs as a function of the number of binding sites in the promoter region

Format: PDF Size: 17KB Download file

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Open Data

Additional data file 2:

A figure depicting the correlation between fit of binding sites to the motif and the length of the motif

Format: PDF Size: 14KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 3:

A figure depicting the distribution of promoters according to the number of associated transcription factors/binding sites

Format: PDF Size: 19KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 4:

A figure depicting average promoter and gene properties as a function of the number of transcription factors

Format: PDF Size: 20KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 5:

A figure depicting average promoter and gene properties as a function of the number of binding sites, for promoters to which exactly one factor binds

Format: PDF Size: 20KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 6:

A figure depicting average promoter and gene properties as a function of the number of binding sites, for promoters for which each factor has exactly one binding site

Format: PDF Size: 20KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional data file 7:

A figure depicting the distribution of correlations between motif length and number of binding sites in randomly shuffled data

Format: PDF Size: 14KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data