Ulysses - an application for the projection of molecular interactions across species

doi:10.1186/gb-2005-6-12-r106

Genome Biology
Volume 6
Issue 12

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Kemmer D
Huang Y
Shah SP
Lim J
Brumm J
Yuen MM
Ling J
Xu T
Wasserman WW
Ouellette BFF

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Huang Y
Shah SP
Lim J
Brumm J
Yuen MM
Ling J
Xu T
Wasserman WW
Ouellette BFF
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Ulysses - an application for the projection of molecular interactions across species

Danielle Kemmer¹^,2 , Yong Huang³ , Sohrab P Shah³^,6 , Jonathan Lim² , Jochen Brumm² , Macaire MS Yuen³ , John Ling³ , Tao Xu³ , Wyeth W Wasserman²^,4 and BF Francis Ouellette³^,4^,5

¹Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden

²Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver V5Z 4H4, BC, Canada

³UBC Bioinformatics Centre, University of British Columbia, Vancouver V6T 1Z4, BC, Canada

⁴Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

⁵Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, BC, Canada

⁶Department of Computer Science, University of British Columbia, Vancouver V6T 1Z4, BC, Canada

author email corresponding author email

Genome Biology 2005, 6:R106doi:10.1186/gb-2005-6-12-r106


Published:	2 December 2005

Subject areas: Bioinformatics, Genome studies

Abstract

We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to perform such Interolog Analysis by the projection of model organism interaction data onto homologous human proteins, and thus serves as an accelerator for the analysis of uncharacterized human proteins. The relevance of projections was assessed and validated against published reference collections. All source code is freely available, and the Ulysses system can be accessed via a web interface http://www.cisreg.ca/ulysses webcite.