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Open Access Software

Ulysses - an application for the projection of molecular interactions across species

Danielle Kemmer12, Yong Huang3, Sohrab P Shah36, Jonathan Lim2, Jochen Brumm2, Macaire MS Yuen3, John Ling3, Tao Xu3, Wyeth W Wasserman24* and BF Francis Ouellette345

Author Affiliations

1 Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden

2 Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver V5Z 4H4, BC, Canada

3 UBC Bioinformatics Centre, University of British Columbia, Vancouver V6T 1Z4, BC, Canada

4 Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

5 Michael Smith Laboratories, University of British Columbia, Vancouver V6T 1Z4, BC, Canada

6 Department of Computer Science, University of British Columbia, Vancouver V6T 1Z4, BC, Canada

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Genome Biology 2005, 6:R106  doi:10.1186/gb-2005-6-12-r106

Published: 2 December 2005

Abstract

We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species. Ulysses was designed to perform such Interolog Analysis by the projection of model organism interaction data onto homologous human proteins, and thus serves as an accelerator for the analysis of uncharacterized human proteins. The relevance of projections was assessed and validated against published reference collections. All source code is freely available, and the Ulysses system can be accessed via a web interface http://www.cisreg.ca/ulysses webcite.