Recent developments in membrane-protein structural genomics
Department of Chemistry and Biochemistry, and the National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
Genome Biology 2005, 6:244 doi:10.1186/gb-2005-6-13-244Published: 3 January 2006
Recent work has identified the topology of almost all the inner membrane proteins in Escherichia coli, and advances in nuclear magnetic resonance spectroscopy now allow the determination of α-helical membrane protein structures at high resolution. Together these developments will help overcome the current limitations of high-throughput determination of membrane protein structures.