Recent developments in membrane-protein structural genomics

doi:10.1186/gb-2005-6-13-244

Genome Biology

Volume 6
Issue 13

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Recent developments in membrane-protein structural genomics

Fei Philip Gao and Timothy A Cross

Department of Chemistry and Biochemistry, and the National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA

author email corresponding author email

Genome Biology 2005, 6:244doi:10.1186/gb-2005-6-13-244


Published:	3 January 2006

Subject areas: Biochemistry and structural biology, Methods, Genome studies, Microbiology and parasitology

Abstract

Recent work has identified the topology of almost all the inner membrane proteins in Escherichia coli, and advances in nuclear magnetic resonance spectroscopy now allow the determination of α-helical membrane protein structures at high resolution. Together these developments will help overcome the current limitations of high-throughput determination of membrane protein structures.