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Recent developments in membrane-protein structural genomics

Fei Philip Gao* and Timothy A Cross

Author Affiliations

Department of Chemistry and Biochemistry, and the National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA

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Genome Biology 2005, 6:244  doi:10.1186/gb-2005-6-13-244

Published: 3 January 2006

Abstract

Recent work has identified the topology of almost all the inner membrane proteins in Escherichia coli, and advances in nuclear magnetic resonance spectroscopy now allow the determination of α-helical membrane protein structures at high resolution. Together these developments will help overcome the current limitations of high-throughput determination of membrane protein structures.