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Proteins that physically interact with AP-2 transcription factors |
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| Protein |
Description |
Domain of AP-2 proteins that interacts* |
Function of interaction |
Reference |
|
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| APC |
Adenomatous polyposis coli tumor suppressor |
Basic region |
Inhibition of β-catenin/TCF/LEF-dependent transcription |
[16] |
| CITED2 |
Coactivator |
DD |
Transcriptional activation |
[69] |
| CITED4 |
Coactivator |
n.d. |
Transcriptional activation |
[70] |
| CDP |
CCAAT displacement protein |
DBD, DD |
Repression of the hamster histone H3.2 promoter |
[71] |
| DEK |
Oncoprotein, chromatin remodeling |
n.d. |
Transcriptional activation |
[72] |
| E1A |
Transforming protein of adenovirus |
DBD, DD |
Repression of AP-2 target genes |
[73] |
| c-Myc |
Oncoprotein |
Carboxyl terminus |
Impairment of Myc/Max DNA-binding and transactivation |
[14] |
| PARP |
PolyADP-ribose polymerase |
Carboxyl terminus |
Transcriptional activation |
[74] |
| PAX-6 |
Transcription factor |
n.d. |
Stimulation of gelatinase B activation |
[75] |
| PC4 |
Coactivator |
Transcriptional activation |
[24] |
|
| P300/CBP |
Coactivator |
Amino terminus |
Transcriptional activation |
[69] |
| p53 |
Tumor suppressor |
n.d. |
Augmentation of p53-dependent transcription |
[76] |
| RAP74 |
Subunit of transcription factor TFIIF |
Central region containing DBD |
Unknown |
[74] |
| Rb |
Retinoblastoma tumor suppressor |
Amino terminus† |
Repression of the hamster histone H3.2 promoter; transcriptional activation of the E-cadherin gene |
[77,78] |
| SP1 |
Transcription factor |
Basic region |
Transcriptional activation of the ovine CYP11A1 gene |
[79] |
| SV40T |
Transforming protein of SV40 virus |
n.d. |
Blocks DNA binding of AP-2 protein |
[12] |
| UBC9 |
E2-conjugating enzyme |
DBD, DD |
Sumoylation |
[80] |
| WWOX |
Tumor suppressor |
Amino terminus PY motif |
Cytoplasmic localization PPPY motif |
[17] |
| YB-1 |
Transcription factor |
n.d. |
Stimulation of gelatinase A transcription |
[81] |
| YY1 |
Transcription factor |
DBD, DD |
Stimulation of the hamster histone H3.2 promoter |
[82] |
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*Abbreviations: DBD, DNA-binding domain; DD, dimerization domain; n.d., not determined. †It is currently not entirely clear whether Rb binds AP-2 only via the amino terminus [78], or whether the DNA-binding domain is also necessary [77]. | ||||
Eckert et al. Genome Biology 2005 6:246 doi:10.1186/gb-2005-6-13-246 |
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