Table 2

Most consistently dysregulated non-chromosome 21 genes based on their p values from ANOVA and after 5% false discovery rate cut-off

Gene name

Accession number

Chromosome number

p value (ANOVA)

Cerebrum

Cerebellum

Astrocyte

Heart


Control

TS21

Control

TS21

Control

TS21

Control

TS21


Hypermethylated in cancer 1 (HIC1)

NM_006497

17

2.33E-08

6.5

1.9

4.8

3.8

4.6

2.0

41.3

5.8

Myomesin 1 (skelemin) (185 kDa) (MYOM1)

NM_003803

18

8.82E-08

37.8

23.3

45.0

52.6

13.6

9.8

930.1

1302.5

Myoglobin (MB)

NM_005368

22

1.09E-07

103.5

85.5

90.2

142.8

72.9

61.1

7392.9

12099.8

Calsequestrin 2 (cardiac muscle) (CASQ2)

NM_001232

1

1.56E-07

17.7

9.3

14.1

19.5

14.4

14.3

2341.5

3868.7

Ras-related associated with diabetes (RRAD)

NM_004165

16

5.06E-06

4.5

4.2

13.3

9.8

45.8

36.6

1907.1

932.0

Troponin I, cardiac (TNNI3)

NM_000363

19

5.90E-06

49.0

44.1

44.6

71.2

31.1

25.2

2942.4

4757.2

Insulin-like growth factor binding protein 7 (IGFBP7)

NM_001553

4

1.12E-05

223.8

314.7

741.5

519.4

2418.6

4205.6

743.8

1137.2

Actin, alpha 1, skeletal muscle (ACTA1)

NM_001100

1

1.20E-05

38.6

38.5

33.7

47.6

55.9

138.1

553.4

2310.0

Calcineurin-binding protein calsarcin-1 (MYOZ2)

NM_016599

4

1.22E-05

4.9

6.3

7.6

20.2

4.7

3.0

1742.3

2592.5

Teratocarcinoma-derived growth factor 1 (TDGF1)

NM_003212

3

1.95E-05

10.6

11.8

8.2

9.9

31.1

20.6

11.3

187.9

Tenomodulin protein (TNMD)

NM_022144

X

2.24E-05

7.2

5.4

10.0

6.4

5.8

4.8

23.6

103.0

Olfactory receptor, family 7, subfamily E, member 12 pseudogene (OR7E12P)

AA459867

13

2.51E-05

115.4

88.7

149.1

87.6

144.8

116.1

215.1

58.4

Cardiac troponin T2 (TNNT2)

X79857

1

2.56E-05

47.4

39.9

47.4

45.7

44.6

32.6

3710.3

4965.9

A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 (ADAMTS8)

NM_007037

11

3.21E-05

13.0

11.5

14.6

15.5

15.1

11.4

282.8

154.7


The average expression values are for the probe sets corresponding to the genes (from MAS5 software). TS21, trisomy 21.

Mao et al. Genome Biology 2005 6:R107   doi:10.1186/gb-2005-6-13-r107

Open Data