Table 5

Most statistically significantly regulated functional groups in the fetal cerebrum tissues based on their p values from t tests

GO group

GO identifier

Number of probe sets

p value

Mean of GO group

Mean of non-group members


Mitochondrion

GO:0005739

417

1.41E-14

0.03

0

Monovalent inorganic cation transporter activity

GO:0015077

86

3.72E-09

0.05

0

Nucleobase, nucleoside, nucleotide and nucleic acid metabolism

GO:0006139

1495

2.00E-07

-0.02

0

Nucleus

GO:0005634

2072

5.50E-07

-0.01

0

Nucleic acid binding

GO:0003676

485

1.23E-06

-0.02

0

Oxidoreductase activity

GO:0016491

299

3.31E-06

0.02

0

NADH dehydrogenase activity

GO:0003954

31

3.80E-06

0.06

0

DNA binding

GO:0003677

1071

1.35E-05

-0.02

0

Cytochrome-c oxidase activity

GO:0004129

25

8.51E-05

0.05

0

RNA binding

GO:0003723

466

1.48E-04

-0.02

0

Transcription factor activity

GO:0003700

558

2.40E-04

-0.02

0

Amine metabolism

GO:0009308

147

3.47E-04

0.03

0

RNA metabolism

GO:0016070

273

7.76E-04

-0.02

0

Heterotrimeric G-protein GTPase, alpha-subunit

GO:0000263

8

8.51E-04

0.04

0

Helicase activity

GO:0004386

27

1.15E-03

-0.05

0


The Gene Ontology (GO) database was used to assign a probe set to a functional group. There were 736 functional groups tested for the cerebrum tissue. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between trisomy 21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ('non-group members'). After one type of multiple test comparison correction, the cut-off level for statistical significance was 6.79E-05 (assigned by dividing 0.05 by the number of functional groups, 736).

Mao et al. Genome Biology 2005 6:R107   doi:10.1186/gb-2005-6-13-r107

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