Table 6

Most statistically significantly regulated functional groups in the fetal cerebellum tissues based on their p values from t tests

GO group

GO identifier

Number of probe sets

p value

Mean of GO group

Mean of non-group members


Integral to plasma membrane

GO:0005887

933

1.26E-11

0.03

0

RNA binding

GO:0003723

469

6.31E-11

-0.02

0.01

Structural constituent of ribosome

GO:0003735

212

1.12E-08

-0.03

0.01

G-protein coupled receptor activity

GO:0004930

212

1.29E-08

0.06

0

Transmission of nerve impulse

GO:0019226

170

3.31E-08

0.06

0

Nucleus

GO:0005634

2194

3.55E-08

-0.01

0.01

Cell surface receptor linked signal transduction

GO:0007166

592

2.24E-07

0.03

0

Ribosome

GO:0005840

147

4.68E-07

-0.03

0.01

Defense response

GO:0006952

430

1.07E-06

0.04

0

Nucleobase, nucleoside, nucleotide and nucleic acid metabolism

GO:0006139

1596

5.37E-06

-0.01

0.01

Neurogenesis

GO:0007399

337

9.55E-06

0.04

0

Eukaryotic translation initiation factor 4 complex

GO:0008304

13

2.51E-05

-0.05

0.01

RNA metabolism

GO:0016070

286

4.57E-05

-0.02

0.01

GABA receptor activity

GO:0016917

15

6.46E-05

0.1

0.01

DNA binding

GO:0003677

1126

7.24E-05

-0.01

0.01


There were 764 functional groups tested. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between TS21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ("non-group members"). After one type of multiple test comparison correction, the cutoff level for statistical significance was 6.54E-05 (assigned by dividing 0.05 by the number of functional groups, 764).

Mao et al. Genome Biology 2005 6:R107   doi:10.1186/gb-2005-6-13-r107

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