Table 7

The most statistically significantly regulated functional groups in the fetal astrocyte cell lines based on their p values from t tests

GO group

GO identifier

Number of probe sets

p value

Mean of GO group

Mean of non-group members


Collagen

GO:0005581

15

7.76E-07

0.33

-0.01

Endoplasmic reticulum

GO:0005783

307

8.91E-07

0.03

-0.02

Fibrillar collagen

GO:0005583

14

5.01E-06

0.29

-0.01

Intracellular non-membrane-bound organelle

GO:0043232

122

7.94E-06

-0.06

-0.01

G-protein coupled receptor activity

GO:0004930

141

1.26E-05

-0.09

-0.01

Gametogenesis

GO:0007276

66

2.45E-05

-0.08

-0.01

Integral to plasma membrane

GO:0005887

734

2.57E-05

-0.04

-0.01

Intramolecular oxidoreductase activity, interconverting keto- and enol-groups

GO:0016862

11

2.19E-04

0.04

-0.01

Carbohydrate transport

GO:0008643

16

2.40E-04

0.1

-0.01

DNA metabolism

GO:0006259

309

3.98E-04

-0.04

-0.01

Extracellular matrix (sensu Metazoa)

GO:0005578

120

6.76E-04

0.09

-0.02

Muscle development

GO:0007517

82

6.76E-04

0.06

-0.01

Defense response

GO:0006952

381

8.51E-04

-0.04

-0.01

Cell adhesion

GO:0007155

227

8.91E-04

0.04

-0.01

MHC class II receptor activity

GO:0045012

12

9.12E-04

-0.12

-0.01


There were 734 functional groups tested. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between trisomy 21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ('non-group members'). After one type of multiple test comparison correction, the cut-off level for statistical significance was 6.81E-05 (assigned by dividing 0.05 by the number of functional groups, 734).

Mao et al. Genome Biology 2005 6:R107   doi:10.1186/gb-2005-6-13-r107

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