Table 8

Most statistically significantly regulated functional groups in the fetal heart tissues based on their p values from t tests

GO group

GO identifier

Number of probe sets

p value

Mean of GO group

Mean of non-group members


Mitochondrion

GO:0005739

446

6.61E-16

0.04

-0.01

Monovalent inorganic cation transporter activity

GO:0015077

86

4.27E-10

0.07

-0.01

Defense response

GO:0006952

485

2.29E-08

-0.06

-0.01

NADH dehydrogenase activity

GO:0003954

31

5.25E-06

0.07

-0.01

Intracellular transport

GO:0046907

428

2.34E-05

0.02

-0.01

Cell-cell signaling

GO:0007267

201

1.02E-04

-0.07

-0.01

Mitochondrial inner membrane

GO:0005743

74

1.66E-04

0.04

-0.01

Cell surface receptor linked signal transduction

GO:0007166

594

1.74E-04

-0.04

-0.01

Integral to plasma membrane

GO:0005887

948

1.95E-04

-0.03

-0.01

Extracellular region

GO:0005576

215

2.40E-04

-0.06

-0.01

Membrane fusion

GO:0006944

14

4.68E-04

0.06

-0.01

DNA metabolism

GO:0006259

322

8.13E-04

0.02

-0.01

Regulation of muscle contraction

GO:0006937

28

9.33E-04

0.08

-0.01

Single-stranded DNA binding

GO:0003697

45

1.38E-03

0.06

-0.01

Electron carrier activity

GO:0009055

12

1.41E-03

0.08

-0.01


There were 769 functional groups tested. The first 12 functional groups with the smallest p values are listed here. The mean of log ratios between trisomy 21 and euploid controls for each functional group was compared to that for the group of remaining probe sets not assigned to that functional group ('non-group members'). After one type of multiple test comparison correction, the cut-off level for statistical significance was 6.50E-05 (assigned by dividing 0.05 by the number of functional groups, 769).

Mao et al. Genome Biology 2005 6:R107   doi:10.1186/gb-2005-6-13-r107

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