Genome Biology

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Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

Hubert Hackl1, Thomas R Burkard1,2, Alexander Sturn1, Renee Rubio3, Alexander Schleiffer2, Sun Tian2, John Quackenbush3, Frank Eisenhaber2 and Zlatko Trajanoski1*

Author Affiliations

1 Institute for Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

2 Research Institute of Molecular Pathology, Dr Bohr-Gasse 7, 1030 Vienna, Austria

3 Dana-Farber Cancer Institute, Department of Biostatistics and Computational Biology, 44 Binney Street, Boston, MA 02115

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Genome Biology 2005, 6:R108 doi:10.1186/gb-2005-6-13-r108

Published: 19 December 2005

Additional files

Additional data file 1:

A spot map for the array design

Format: TXT Size: 2.5MB Download file

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Additional data file 2:

A fasta file containing the EST sequences used for the array

Format: ZIP Size: 4MB Download file

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Additional data file 3:

An Excel file containing expression values for the 780 selected ESTs

Format: XLS Size: 159KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 4:

An Excel file containing expression values for the 5205 ESTs filtered with ANOVA

Format: XLS Size: 3.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 5:

GenePix result files containing raw data

Format: ZIP Size: 5.3MB Download file

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Additional data file 6:

Images showing the distribution of gene ontology

Format: PDF Size: 5.6MB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional data file 7:

A table listing relevant proteins

Format: XLS Size: 182KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 8:

A fasta file containing sequences of the relevant proteins

Format: FA Size: 674KB Download file

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Additional data file 9:

A pdf file containing real-time RT-PCR data

Format: PDF Size: 71KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional data file 10:

A table including statistical analysis of independent experiments

Format: XLS Size: 16KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 11:

A figure showing a comparison with GeneAtlas

Format: PNG Size: 914KB Download file

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Additional data file 12:

A table including expression levels from the present study and GeneAtlas

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 13:

A figure showing a comparison with the data set reported by Soukas and coworkers [8]

Format: PNG Size: 236KB Download file

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Additional data file 14:

A figure showing a comparison with the data set reported by Ross and coworkers [9]

Format: PNG Size: 336KB Download file

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Additional data file 15:

A figure showing a comparison with the data set reported by Burton and coworkers [12]

Format: PNG Size: 348KB Download file

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Additional data file 16:

A table including ESTs unique to the present study

Format: XLS Size: 69KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 17:

A figure showing genes with miRNA motifs in 3'-UTR

Format: PNG Size: 918KB Download file

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Additional data file 18:

A figure illustrating the significant over-representation of miRNA motifs in the 3'-UTR of genes in each cluster

Format: PNG Size: 99KB Download file

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Additional data file 19:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 1

Format: PNG Size: 7KB Download file

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Additional data file 20:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 2

Format: PNG Size: 17KB Download file

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Additional data file 21:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 3

Format: PNG Size: 9KB Download file

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Additional data file 22:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 4

Format: PNG Size: 12KB Download file

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Additional data file 23:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 6

Format: PNG Size: 13KB Download file

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Additional data file 24:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 7

Format: PNG Size: 7KB Download file

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Additional data file 25:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 8

Format: PNG Size: 35KB Download file

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Additional data file 26:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 9

Format: PNG Size: 39KB Download file

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Additional data file 27:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 10

Format: PNG Size: 24KB Download file

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Additional data file 28:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 11

Format: PNG Size: 9KB Download file

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Additional data file 29:

A figure showing the significant over-representation of miRNA motifs in the 3'-UTR from genes in cluster 12

Format: PNG Size: 27KB Download file

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Additional data file 30:

A table including over-represented miRNA motifs in the 3'-UTR from genes in the set of 780 selected ESTs

Format: XLS Size: 29KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 31:

Text describing regulation of metabolic pathways

Format: PDF Size: 49KB Download file

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Additional data file 32:

A figure showing regulation of metabolic pathways by key points

Format: PDF Size: 611KB Download file

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Additional data file 33:

Figure showing the cellular localization of gene products involved in metabolism and their gene expression at different time points

Format: PDF Size: 1.7MB Download file

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Additional data file 34:

Figure showing the cellular localization of gene products involved in other biological processes and their gene expression at different time points

Format: PDF Size: 1.9MB Download file

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Additional data file 35:

Text describing signaling networks

Format: PDF Size: 96KB Download file

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Additional data file 36:

A text file describing extracellular matrix remodeling and cytoskeleton reorganization

Format: PDF Size: 48KB Download file

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Additional data file 37:

A figure showing cell cycle processes

Format: PDF Size: 285KB Download file

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Additional data file 38:

A figure showing the cholesterol pathway

Format: PDF Size: 75KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional data file 39:

A list of experimental verified binding site for PPAR:RXR and the derived position weight matrix

Format: PDF Size: 137KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional data file 40:

Text file containing TRANSFAC matrices for vertebrates

Format: TXT Size: 32KB Download file

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Additional data file 41:

A file showing the promoter sequences in fasta format

Format: FA Size: 1.5MB Download file

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Additional data file 42:

A file showing the promoter sequences in fasta format

Format: PDF Size: 194KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional data file 43:

A figure showing clusterwise mapping of 780 ESTs to all chromosomes

Format: PDF Size: 336KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional data file 44:

An Excel file showing a statistical analysis of colocalized ESTs for 780 selected ESTs

Format: XLS Size: 23KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional data file 45:

An Excel file showing a statistical analysis of colocalized ESTs for 5,502 ANOVA selected ESTs

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data