Table 3 |
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|
Significance of occurrence of predicted SREBP-1 binding sites in the promoters of co-expressed genes identified by clustering |
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|
SREBP-1 |
Putative target genes |
Genes in cluster |
Against total PromoSer database |
Against total of all clusters |
||
|
|
||||||
|
CS |
FE |
CS |
FE |
|||
|
|
||||||
|
Cluster 1 |
4 |
10 |
0.5000 |
0.7051 |
0.5339 |
0.7644 |
|
Cluster 2 |
11 |
27 |
0.5448 |
0.6892 |
0.6475 |
0.7812 |
|
Cluster 3 |
5 |
16 |
0.7076 |
0.8575 |
0.7697 |
0.8987 |
|
Cluster 4 |
9 |
12 |
0.0290 |
0.0289 |
0.0494 |
0.0484 |
|
Cluster 5 |
16 |
45 |
0.7787 |
0.8570 |
0.8568 |
0.9171 |
|
Cluster 6 |
10 |
20 |
0.1553 |
0.1554 |
0.2278 |
0.2277 |
|
Cluster 7 |
5 |
10 |
0.5000 |
0.5677 |
0.5000 |
0.6423 |
|
Cluster 8 |
31 |
66 |
0.2837 |
0.2827 |
0.4719 |
0.4711 |
|
Cluster 9 |
12 |
42 |
0.9025 |
0.9454 |
0.9414 |
0.9708 |
|
Cluster 10 |
22 |
41 |
0.1635 |
0.1635 |
0.2881 |
0.2877 |
|
Cluster 11 |
8 |
15 |
0.3230 |
0.3204 |
0.4057 |
0.4041 |
|
Cluster 12 |
25 |
45 |
0.0398 |
0.0404 |
0.1014 |
0.1014 |
|
PromoSer |
5,456 |
12,493 |
||||
|
|
||||||
|
Probabilities for over-representation (<0.05) of genes having a predicted SREBP-1 site relative to all unique regulated genes of PromoSer and to the total of all clusters. Cluster 4 is the only one with significantly increased occurrence of predicted SREBP-1 binding sites. CS, one-sided χ2 test; FE, one-sided Fisher's exact test; SREBP, sterol-regulatory element binding protein. |
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|
Hackl et al. Genome Biology 2005 6:R108 doi:10.1186/gb-2005-6-13-r108 |
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