Table 1

Comparison of wTF2.0 versus wTF1.0
DNA binding domain
 Description
 wTF2.0
 wTF1.0




WP140 22,420
 Family members in humans
 Ortholog pairs
 Clarke
1998
WP14
14,655 [16]
 Ruvkun 1998 WP15 15,558 [15]
 Rubin 2000 WP18 18,576
 Reichaman 2000 WP20 19,101 [18]
AP-2
 Activator protein-2
 4
 5
 0
 -
 -
 -
 4
ARID/BRIGHT
 AT-rich interaction domain
 4
 9
 2
 -
 -
 -
 4
AT HOOK
31
 28
 5
 -
 -
 -
 -
BHLH
 basic region helix loop helix
 42
 103
 22
 -
 24
 -
 25
BZIP
 basic region leucine zipper
 32
 57
 11
 -
 18
 18
 25
CBF
 CCAAT-binding factor
 9
 12
 7
 -
 -
 -
 -
COLD BOX
5
 11
 2
 -
 -
 -
 -
CP2
1
 6
 1
 -
 -
 -
 -
HD
 Homeodomain
 99
 167
 36
 -
 83
 88
 84
HMG
 High mobility group
 16
 59
 12
 -
 -
 -
 15
HTH
 Helix turn helix
 2
 12
 2
 -
 -
 -
 -
IPT/TIG
 Ig-like, plexins, TFs
 3
 8
 2
 -
 -
 -
 -
MADF
 Mothers against Dpp factor
 9
 0
 0
 -
 -
 -
 -
MADS box
 MCM1/AG/DEF/SRF
 2
 5
 2
 -
 -
 -
 2
MH1
 MAD homology 1
 7
 12
 1
 -
 -
 -
 -
MYB
19
 21
 8
 -
 -
 16
 3
p53
3
 3
 1
 -
 -
 -
 0
PD-FULL
 Paired domain
 5
 9
 1*
 -
 5
 -
 -
PD-NPAX
 Paired domain
 4
 0
 0
 -
 -
 -
 -
PD-CPAX
 Paired domain
 1
 0
 0
 -
 -
 -
 -
PD-UNDEFINED
 Paired domain
 -
 -
 -
 -
 -
 11†
 10†
RPEL
1
 3
 1
 -
 -
 -
 -
RUNT
1
 6
 1
 -
 -
 -
 1
SAND
 Sp100, AIRE-1, NucP41/75, DEAF-1
 4
 8
 1*
 -
 -
 -
 -
STAT
 Signal transducers and activators of transcription
 2
 7
 0
 -
 -
 -
 1
T-BOX
21
 17
 2
 -
 17
 -
 21
TEA/ATTS
 Transcriptional enhancer activator
 1
 4
 1
 -
 -
 -
 -
TSC-22/DIP/BUN
3
 4
 0
 -
 -
 -
 1
WH-DAC
 Dachshund
 1
 2
 1
 -
 -
 -
 -
WH-ETS
 Erythroblast transformation specific
 10
 15
 5
 -
 10
 -
 10
WH-FH
 Fork head
 18
 41
 4
 -
 15
 19
 15
WH-HSF
 Heat shock factor
 2
 8
 1
 -
 -
 -
 1
WH-RFX
 X-box binding regulatory factor
 1
 3
 0
 -
 -
 -
 1
WH-TDP
 TF E2F dimerisation partner
 4
 11
 2
 -
 -
 -
 4
WH-UNDEFINED
 Winged helix
 4
 0
 0
 -
 -
 -
 -
WT1
 Wilms tumor1
 1
 17
 0
 -
 -
 -
 -
YL1
1
 1
 1
 -
 -
 -
 -
ZF-A20
 Zinc finger, A20-type
 2
 6
 2
 -
 -
 -
 -
ZF-BED
 BEAF/DREF-like ZF
 6
 4
 1
 -
 -
 -
 -
ZF-C2H2
211
 391
 35
 117
 -
 138
 139
ZF-C2HC
1
 6
 1
 -
 -
 -
 -
ZF-CCCH
32
 50
 8
 20
 -
 -
 15
ZF-DHHC
15
 21
 7
 -
 -
 13
 -
ZF-DM
 Dsx and Mab-3-like ZF
 11
 7
 0
 8
 -
 -
 9
ZF-FLYWCH
4
 1
 0
 -
 -
 -
 -
ZF-GATA
14
 7
 3
 9
 -
 -
 9
ZF-MIZ
 Msx interacting ZF
 2
 6
 1
 -
 -
 -
 -
ZF-NF-X1
 Nuclear factor
 2
 3
 2
 -
 -
 -
 -
ZF-NHR/C4
 Nuclear hormone receptor
 274
 43
 6
 233
 235
 224
 252
ZF-THAP
5
 12
 2
 -
 -
 -
 -
UNKNOWN
5
 0
 2
 -
 -
 -
 -
TOTAL
957‡
 1,231
 203
 387
 407
 527
 652

This table shows the number of genes encoding each type of domain. Genes encoding multiple domains of the same type are counted only once. Dashes indicate the domain was not investigated. *These genes encode two distinct domains: PD and HD; SAND and AT hook. †Without access to the complete Rubin and Reichmann lists, we are unable to classify their PD family members. ‡Twenty-three genes in wTF2.0 encode two different types of domain.

Reece-Hoyes et al. Genome Biology 2005 6:R110   doi:10.1186/gb-2005-6-13-r110

Open Data