Table 1 |
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|
Comparison of wTF2.0 versus wTF1.0 |
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|
DNA binding domain |
Description |
wTF2.0 |
wTF1.0 |
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|
|
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|
WP140 22,420 |
Family members in humans |
Ortholog pairs |
Clarke 1998 WP14 14,655 [16] |
Ruvkun 1998 WP15 15,558 [15] |
Rubin 2000 WP18 18,576 |
Reichaman 2000 WP20 19,101 [18] |
||
|
|
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|
AP-2 |
Activator protein-2 |
4 |
5 |
0 |
- |
- |
- |
4 |
|
ARID/BRIGHT |
AT-rich interaction domain |
4 |
9 |
2 |
- |
- |
- |
4 |
|
AT HOOK |
31 |
28 |
5 |
- |
- |
- |
- |
|
|
BHLH |
basic region helix loop helix |
42 |
103 |
22 |
- |
24 |
- |
25 |
|
BZIP |
basic region leucine zipper |
32 |
57 |
11 |
- |
18 |
18 |
25 |
|
CBF |
CCAAT-binding factor |
9 |
12 |
7 |
- |
- |
- |
- |
|
COLD BOX |
5 |
11 |
2 |
- |
- |
- |
- |
|
|
CP2 |
1 |
6 |
1 |
- |
- |
- |
- |
|
|
HD |
Homeodomain |
99 |
167 |
36 |
- |
83 |
88 |
84 |
|
HMG |
High mobility group |
16 |
59 |
12 |
- |
- |
- |
15 |
|
HTH |
Helix turn helix |
2 |
12 |
2 |
- |
- |
- |
- |
|
IPT/TIG |
Ig-like, plexins, TFs |
3 |
8 |
2 |
- |
- |
- |
- |
|
MADF |
Mothers against Dpp factor |
9 |
0 |
0 |
- |
- |
- |
- |
|
MADS box |
MCM1/AG/DEF/SRF |
2 |
5 |
2 |
- |
- |
- |
2 |
|
MH1 |
MAD homology 1 |
7 |
12 |
1 |
- |
- |
- |
- |
|
MYB |
19 |
21 |
8 |
- |
- |
16 |
3 |
|
|
p53 |
3 |
3 |
1 |
- |
- |
- |
0 |
|
|
PD-FULL |
Paired domain |
5 |
9 |
1* |
- |
5 |
- |
- |
|
PD-NPAX |
Paired domain |
4 |
0 |
0 |
- |
- |
- |
- |
|
PD-CPAX |
Paired domain |
1 |
0 |
0 |
- |
- |
- |
- |
|
PD-UNDEFINED |
Paired domain |
- |
- |
- |
- |
- |
11† |
10† |
|
RPEL |
1 |
3 |
1 |
- |
- |
- |
- |
|
|
RUNT |
1 |
6 |
1 |
- |
- |
- |
1 |
|
|
SAND |
Sp100, AIRE-1, NucP41/75, DEAF-1 |
4 |
8 |
1* |
- |
- |
- |
- |
|
STAT |
Signal transducers and activators of transcription |
2 |
7 |
0 |
- |
- |
- |
1 |
|
T-BOX |
21 |
17 |
2 |
- |
17 |
- |
21 |
|
|
TEA/ATTS |
Transcriptional enhancer activator |
1 |
4 |
1 |
- |
- |
- |
- |
|
TSC-22/DIP/BUN |
3 |
4 |
0 |
- |
- |
- |
1 |
|
|
WH-DAC |
Dachshund |
1 |
2 |
1 |
- |
- |
- |
- |
|
WH-ETS |
Erythroblast transformation specific |
10 |
15 |
5 |
- |
10 |
- |
10 |
|
WH-FH |
Fork head |
18 |
41 |
4 |
- |
15 |
19 |
15 |
|
WH-HSF |
Heat shock factor |
2 |
8 |
1 |
- |
- |
- |
1 |
|
WH-RFX |
X-box binding regulatory factor |
1 |
3 |
0 |
- |
- |
- |
1 |
|
WH-TDP |
TF E2F dimerisation partner |
4 |
11 |
2 |
- |
- |
- |
4 |
|
WH-UNDEFINED |
Winged helix |
4 |
0 |
0 |
- |
- |
- |
- |
|
WT1 |
Wilms tumor1 |
1 |
17 |
0 |
- |
- |
- |
- |
|
YL1 |
1 |
1 |
1 |
- |
- |
- |
- |
|
|
ZF-A20 |
Zinc finger, A20-type |
2 |
6 |
2 |
- |
- |
- |
- |
|
ZF-BED |
BEAF/DREF-like ZF |
6 |
4 |
1 |
- |
- |
- |
- |
|
ZF-C2H2 |
211 |
391 |
35 |
117 |
- |
138 |
139 |
|
|
ZF-C2HC |
1 |
6 |
1 |
- |
- |
- |
- |
|
|
ZF-CCCH |
32 |
50 |
8 |
20 |
- |
- |
15 |
|
|
ZF-DHHC |
15 |
21 |
7 |
- |
- |
13 |
- |
|
|
ZF-DM |
Dsx and Mab-3-like ZF |
11 |
7 |
0 |
8 |
- |
- |
9 |
|
ZF-FLYWCH |
4 |
1 |
0 |
- |
- |
- |
- |
|
|
ZF-GATA |
14 |
7 |
3 |
9 |
- |
- |
9 |
|
|
ZF-MIZ |
Msx interacting ZF |
2 |
6 |
1 |
- |
- |
- |
- |
|
ZF-NF-X1 |
Nuclear factor |
2 |
3 |
2 |
- |
- |
- |
- |
|
ZF-NHR/C4 |
Nuclear hormone receptor |
274 |
43 |
6 |
233 |
235 |
224 |
252 |
|
ZF-THAP |
5 |
12 |
2 |
- |
- |
- |
- |
|
|
UNKNOWN |
5 |
0 |
2 |
- |
- |
- |
- |
|
|
TOTAL |
957‡ |
1,231 |
203 |
387 |
407 |
527 |
652 |
|
|
|
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|
This table shows the number of genes encoding each type of domain. Genes encoding multiple domains of the same type are counted only once. Dashes indicate the domain was not investigated. *These genes encode two distinct domains: PD and HD; SAND and AT hook. †Without access to the complete Rubin and Reichmann lists, we are unable to classify their PD family members. ‡Twenty-three genes in wTF2.0 encode two different types of domain. |
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|
Reece-Hoyes et al. Genome Biology 2005 6:R110 doi:10.1186/gb-2005-6-13-r110 |
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