Table 1

Comparison of wTF2.0 versus wTF1.0

DNA binding domain

Description

wTF2.0

wTF1.0


WP140 22,420

Family members in humans

Ortholog pairs

Clarke

1998

WP14

14,655 [16]

Ruvkun 1998 WP15 15,558 [15]

Rubin 2000 WP18 18,576

Reichaman 2000 WP20 19,101 [18]


AP-2

Activator protein-2

4

5

0

-

-

-

4

ARID/BRIGHT

AT-rich interaction domain

4

9

2

-

-

-

4

AT HOOK

31

28

5

-

-

-

-

BHLH

basic region helix loop helix

42

103

22

-

24

-

25

BZIP

basic region leucine zipper

32

57

11

-

18

18

25

CBF

CCAAT-binding factor

9

12

7

-

-

-

-

COLD BOX

5

11

2

-

-

-

-

CP2

1

6

1

-

-

-

-

HD

Homeodomain

99

167

36

-

83

88

84

HMG

High mobility group

16

59

12

-

-

-

15

HTH

Helix turn helix

2

12

2

-

-

-

-

IPT/TIG

Ig-like, plexins, TFs

3

8

2

-

-

-

-

MADF

Mothers against Dpp factor

9

0

0

-

-

-

-

MADS box

MCM1/AG/DEF/SRF

2

5

2

-

-

-

2

MH1

MAD homology 1

7

12

1

-

-

-

-

MYB

19

21

8

-

-

16

3

p53

3

3

1

-

-

-

0

PD-FULL

Paired domain

5

9

1*

-

5

-

-

PD-NPAX

Paired domain

4

0

0

-

-

-

-

PD-CPAX

Paired domain

1

0

0

-

-

-

-

PD-UNDEFINED

Paired domain

-

-

-

-

-

11

10

RPEL

1

3

1

-

-

-

-

RUNT

1

6

1

-

-

-

1

SAND

Sp100, AIRE-1, NucP41/75, DEAF-1

4

8

1*

-

-

-

-

STAT

Signal transducers and activators of transcription

2

7

0

-

-

-

1

T-BOX

21

17

2

-

17

-

21

TEA/ATTS

Transcriptional enhancer activator

1

4

1

-

-

-

-

TSC-22/DIP/BUN

3

4

0

-

-

-

1

WH-DAC

Dachshund

1

2

1

-

-

-

-

WH-ETS

Erythroblast transformation specific

10

15

5

-

10

-

10

WH-FH

Fork head

18

41

4

-

15

19

15

WH-HSF

Heat shock factor

2

8

1

-

-

-

1

WH-RFX

X-box binding regulatory factor

1

3

0

-

-

-

1

WH-TDP

TF E2F dimerisation partner

4

11

2

-

-

-

4

WH-UNDEFINED

Winged helix

4

0

0

-

-

-

-

WT1

Wilms tumor1

1

17

0

-

-

-

-

YL1

1

1

1

-

-

-

-

ZF-A20

Zinc finger, A20-type

2

6

2

-

-

-

-

ZF-BED

BEAF/DREF-like ZF

6

4

1

-

-

-

-

ZF-C2H2

211

391

35

117

-

138

139

ZF-C2HC

1

6

1

-

-

-

-

ZF-CCCH

32

50

8

20

-

-

15

ZF-DHHC

15

21

7

-

-

13

-

ZF-DM

Dsx and Mab-3-like ZF

11

7

0

8

-

-

9

ZF-FLYWCH

4

1

0

-

-

-

-

ZF-GATA

14

7

3

9

-

-

9

ZF-MIZ

Msx interacting ZF

2

6

1

-

-

-

-

ZF-NF-X1

Nuclear factor

2

3

2

-

-

-

-

ZF-NHR/C4

Nuclear hormone receptor

274

43

6

233

235

224

252

ZF-THAP

5

12

2

-

-

-

-

UNKNOWN

5

0

2

-

-

-

-

TOTAL

957

1,231

203

387

407

527

652


This table shows the number of genes encoding each type of domain. Genes encoding multiple domains of the same type are counted only once. Dashes indicate the domain was not investigated. *These genes encode two distinct domains: PD and HD; SAND and AT hook. Without access to the complete Rubin and Reichmann lists, we are unable to classify their PD family members. Twenty-three genes in wTF2.0 encode two different types of domain.

Reece-Hoyes et al. Genome Biology 2005 6:R110   doi:10.1186/gb-2005-6-13-r110

Open Data