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Functional analysis of gene expression differences between autopsy and resection samples |
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| GO ID |
Term |
Expressed genes |
Significant differences* |
Change p value |
Conservation p value |
|
|
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| GO:0006412 |
Protein biosynthesis |
462 |
101 (37/64) |
0.001 |
0.999 |
| GO:0006512 |
Ubiquitin cycle |
473 |
119 (86/33) |
0.000 |
1.000 |
| GO:0016567 |
Protein ubiquitination |
256 |
60 (41/19) |
0.002 |
0.999 |
| GO:0006511 |
Ubiquitin-dependent protein catabolism |
104 |
36 (23/13) |
0.000 |
1.000 |
| GO:0006396 |
RNA processing |
341 |
118 (64/54) |
0.011 |
0.995 |
| GO:0006397 |
mRNA processing |
217 |
74 (44/30) |
0.002 |
0.999 |
| GO:0008380 |
RNA splicing |
183 |
67 (39/28) |
0.000 |
1.000 |
| GO:0006281 |
DNA repair |
168 |
40 (23/17) |
0.009 |
0.995 |
| GO:0000398 |
Nuclear mRNA splicing, via spliceosome |
155 |
54 (30/24) |
0.000 |
1.000 |
| GO:0006364 |
rRNA processing |
32 |
16 (3/13) |
0.000 |
1.000 |
| GO:0006996 |
Organelle organization and biogenesis |
367 |
83 (30/53) |
0.048 |
0.964 |
| GO:0006886 |
Intracellular protein transport |
263 |
62 (32/30) |
0.002 |
0.999 |
| GO:0008624 |
Induction of apoptosis by extracellular signals |
28 |
13 (2/11) |
0.000 |
1.000 |
| GO:0006120 |
Electron transport, NADH to ubiquinone |
24 |
10 (3/7) |
0.003 |
0.999 |
| GO:0048247 |
Lymphocyte chemotaxis |
3 |
3 (0/3) |
0.004 |
1.000 |
| GO:0007242 |
Intracellular signaling cascade |
879 |
105 |
0.989 |
0.016 |
| GO:0007186 |
GPCR protein signaling pathway |
448 |
39 |
1.000 |
0.000 |
| GO:0007267 |
Cell-cell signaling |
417 |
39 |
0.998 |
0.003 |
| GO:0007243 |
Protein kinase cascade |
231 |
24 |
0.997 |
0.005 |
| GO:0045860 |
Positive regulation of protein kinase activity |
41 |
1 |
0.999 |
0.006 |
| GO:0007268 |
Synaptic transmission |
203 |
18 |
0.999 |
0.001 |
| GO:0007187 |
G-protein signaling (cyclic nucleotide second messenger) |
73 |
4 |
0.999 |
0.004 |
| GO:0050896 |
Response to stimulus |
1,326 |
179 |
0.975 |
0.035 |
| GO:0009605 |
Response to external stimulus |
781 |
90 |
0.972 |
0.037 |
| GO:0009617 |
Response to bacteria |
37 |
0 |
1.000 |
0.001 |
| GO:0007601 |
Visual perception |
126 |
9 |
0.999 |
0.002 |
| GO:0007606 |
Sensory perception of chemical stimulus |
55 |
2 |
0.999 |
0.003 |
| GO:0007275 |
Development |
1,412 |
174 |
0.992 |
0.011 |
| GO:0009887 |
Organogenesis |
770 |
89 |
0.997 |
0.004 |
| GO:0007417 |
Central nervous system development |
92 |
6 |
0.999 |
0.004 |
| GO:0008544 |
Epidermis development |
39 |
1 |
0.999 |
0.008 |
| GO:0050875 |
Cellular physiological process |
3,372 |
515 |
1.000 |
0.000 |
| GO:0050874 |
Organismal physiological process |
1,200 |
138 |
0.997 |
0.004 |
| GO:0006813 |
Potassium ion transport |
139 |
3 |
1.000 |
0.000 |
| GO:0030003 |
Cation homeostasis |
52 |
1 |
1.000 |
0.001 |
|
*Numbers in parenthesis correspond to the number of up- and down-regulated genes in the autopsy samples. Bold font indicates Gene Ontology (GO) groups with significant excess of up- or down-regulated genes (see Materials and methods). | |||||
Franz et al. Genome Biology 2005 6:R112 doi:10.1186/gb-2005-6-13-r112 |
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