Temporal and spatial patterning of an organ by a single transcription factor

doi:10.1186/gb-2005-6-2-205

Genome Biology

Volume 6
Issue 2

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Temporal and spatial patterning of an organ by a single transcription factor

Diya Banerjee and Frank J Slack

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA

author email corresponding author email

Genome Biology 2005, 6:205doi:10.1186/gb-2005-6-2-205


Published:	25 January 2005

Subject areas: Development, Genome studies, Genetics, Molecular biology

Abstract

During the formation of animal organs, a single regulatory factor can control the majority of cell-fate decisions, but the mechanisms by which this occurs are poorly understood. One such regulator, the nematode transcription factor PHA-4, functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.