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Protein family review

The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

David IR Holmes12 and Ian Zachary1*

Author affiliations

1 BHF Laboratories and The Rayne Institute, Department of Medicine, University College London, 5 University Street, London WC1E 6JJ, UK

2 Ark Therapeutics Ltd, 1 Fitzroy Mews, London W1T 6DE, UK

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Citation and License

Genome Biology 2005, 6:209  doi:10.1186/gb-2005-6-2-209

Published: 1 February 2005

Abstract

Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with a highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived growth factors. VEGF-A, the founding member of the family, is highly conserved between animals as evolutionarily distant as fish and mammals. In vertebrates, VEGFs act through a family of cognate receptor kinases in endothelial cells to stimulate blood-vessel formation. VEGF-A has important roles in mammalian vascular development and in diseases involving abnormal growth of blood vessels; other VEGFs are also involved in the development of lymphatic vessels and disease-related angiogenesis. Invertebrate homologs of VEGFs and VEGF receptors have been identified in fly, nematode and jellyfish, where they function in developmental cell migration and neurogenesis. The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions.