|
Isoforms of human VEGF-A |
|||
| Isoform |
Size (amino acids) |
Coding exons* |
Features |
|
|
|||
| VEGF-A121 |
121 |
1-5, 8 |
Secreted |
| VEGF-A145 |
145 |
1-6, 8 |
Binds NRP2 but not NRP1; secreted |
| VEGF-A165 |
165 |
1-5, 7, 8 |
The most abundant and biologically active isoform; secreted; binds NRP1 and NRP2 |
| VEGF-A165b |
165 |
1-5, 7, alternative exon 8 |
Secreted, endogenous inhibitory form of VEGF-A165 |
| VEGF-A183 |
183 |
1-5, short exon 6, 7, 8 |
Sequestered in ECM but released by cleavage |
| VEGF-A189 |
189 |
1-8 |
Sequestered in ECM but released by cleavage |
| VEGF-A206 |
206 |
1-8 plus additional exon 6-encoded sequence |
Sequestered in ECM but released by cleavage |
|
*All isoforms contain exons 1-5 and 8, except VEGF-A165b, which contains an alternative exon 8. Abbreviations: ECM, extracellular matrix; NRP, neuropilin. | |||
Holmes and Zachary Genome Biology 2005 6:209 doi:10.1186/gb-2005-6-2-209 |
|||