Table 2

Isoforms of human VEGF-A

Isoform

Size (amino acids)

Coding exons*

Features


VEGF-A121

121

1-5, 8

Secreted

VEGF-A145

145

1-6, 8

Binds NRP2 but not NRP1; secreted

VEGF-A165

165

1-5, 7, 8

The most abundant and biologically active isoform; secreted; binds NRP1 and NRP2

VEGF-A165b

165

1-5, 7, alternative exon 8

Secreted, endogenous inhibitory form of VEGF-A165

VEGF-A183

183

1-5, short exon 6, 7, 8

Sequestered in ECM but released by cleavage

VEGF-A189

189

1-8

Sequestered in ECM but released by cleavage

VEGF-A206

206

1-8 plus additional exon 6-encoded sequence

Sequestered in ECM but released by cleavage


*All isoforms contain exons 1-5 and 8, except VEGF-A165b, which contains an alternative exon 8. Abbreviations: ECM, extracellular matrix; NRP, neuropilin.

Holmes and Zachary Genome Biology 2005 6:209   doi:10.1186/gb-2005-6-2-209