Figure 4.

Association of genomic localization with co-regulation of expression. (a,b) Chromosomal gene clusters contain highly correlated expression changes among multiple members. Global patterns of gene expression within these genomic intervals are visualized by representing mean log expression for four of the myometrium time-point groups (non-pregnant, 14.5 and 18.5 days gestation, and 24 h postpartum), versus relative gene position on the chromosome. Gene strand orientation and position is designated by the orientation of arrows. Gene symbols above and below arrows are shown, where italicized black text indicates co-regulated genes (same HOPACH cluster) and italicized gray genes not co-regulated for (a) increased quiescence and (b) increased postpartum involution. Non-italicized gray text indicates genes not probed by the arrays.