Table 1

Genes upregulated with quiescence

Increased gestation pattern group

Gene symbol

Fold-change at 14 days


Prostaglandin and cortisol synthesis

Hydroxysteroid 11-beta dehydrogenase 1

Hsd11b1

10.6

Decidual/trophoblast prolactin-related protein

Dtprp

6.2

Hydroxysteroid 11-beta dehydrogenase 2

Hsd11b2

3.6

Cytochrome P450, 11a

Cyp11a1

2.3

Prostaglandin-endoperoxide synthase 1

Ptgs1

2.0

Phospholipase inhibition

Annexin A8

Anxa8

4.4

Annexin A3

Anxa3

3.1

Uteroglobin

Utg

2.7

Calpactin

S100a10

2.5

Annexin A1

Anxa1

2.4

Annexin A2

Anxa2

2.1

Proteolysis and peptidolysis

Kidney-derived aspartic protease-like protein

Kdap

8.2

CTLA-2-beta

Ctla2b

8.1

Cathepsin Z

Ctsz

3.1

Dipeptidase 1

Dpep1

3.1

Procollagen C-proteinase enhancer protein

Pcolce

2.6

Lipocalin 7

Lcn7

2.6

Serine-type endopeptidases

Granzyme G

Gzmg

71.4

Granzyme D

Gzmd

45.7

Granzyme F

Gzmf

40.2

Granzyme E

Gzme

19.8

Granzyme C

Gzmc

10.7

RIKEN cDNA 2210021K23 gene

2210021K23Rik

2.9

Cathepsin G

Ctsg

2.2

Protease, serine, 11 (Igf binding)

Prss11

2.2

Granzyme B

Gzmb

2.1

Protease inhibitors

Tissue factor pathway inhibitor 2

Tfpi2

4.2

Serine protease inhibitor 14

Serpinb9e

3.3

Plasma protease C1 inhibitor

Serping1

2.7

Extracellular matrix remodeling and cell growth

Regulation of cell growth

Insulin-like growth factor binding protein 2

Igfbp2

12.4

Interleukin 1 receptor, type II

Il1r2

5.0

Glucocorticoid-induced leucine zipper

Gilz

3.8

Tumor necrosis factor, alpha-induced protein 2

Tnfaip2

3.3

c-Fos induced growth factor

Figf

3.2

Related RAS viral (r-ras) oncogene homolog 2

Rras2

3.0

Cysteine rich protein 2

Crip2

2.9

MORF-related gene X

Morf4l2

2.6

Epithelial membrane protein 1

Emp1

2.5

Four and a half LIM domains 1

Fhl1

2.3

S100 calcium binding protein A6 (calcyclin)

S100a6

2.3

Insulin-like growth factor binding protein 6

Igfbp6

2.1

Transforming growth factor, beta 2

Tgfb2

2.0

Integrin-mediated signaling pathway

Secreted phosphoprotein 1

Spp1

17.3

Connective tissue growth factor

Ctgf

2.8

Caveolin, caveolae protein

Cav

2.5

Ras homolog gene family, member A2

Arha

2.4

Structural constituent of cytoskeleton

Gelsolin

Gsn

2.4

Tropomyosin 4

Tpm4

3.1

Tubulin, beta 2

Tubb2

2.2

Extracellular matrix structural constituent

Microfibrillar associated protein 5

Mfap5-pending

6.9

Elastin

Eln

3.1

Procollagen, type XI, alpha 1

Col11a1

3.0

Fibromodulin

Fmod

2.4

Fibrillin 1

Fbn1

2.3

Procollagen, type V, alpha 2

Col5a2

2.2

Laminin, gamma 1

Lamc1

2.2

Procollagen, type I, alpha 2

Col1a2

2.2

G-protein signaling

Guanylate cyclase activator 2b

Guca2b

15.2

Chemokine orphan receptor 1

Cmkor1

5.0

Adrenomedullin

Adm

2.0

Guanine nucleotide binding protein, gamma 11

Gng11

2.0

Transcriptional regulation

Secreted frizzled-related sequence protein 4

Sfrp4

4.2

Kruppel-like factor 4

Klf4

3.0

C/EBP delta

Cebpd

2.3

Inhibitor of DNA binding 1

Idb1

2.1

X-box binding protein 1

Xbp1

2.0

Kruppel-like factor 2

Klf2

2.0


Only upregulated genes with a relative fold-change of 2 or more versus non-pregnant mice at 14.5 days gestation and linked to biological categories highlighted by the expression analysis are shown. Full gene lists can be obtained online (see Additional data file 6).

Salomonis et al. Genome Biology 2005 6:R12   doi:10.1186/gb-2005-6-2-r12

Open Data