|
Genes upregulated with quiescence |
||
| Increased gestation pattern group |
Gene symbol |
Fold-change at 14 days |
|
|
||
| Prostaglandin and cortisol synthesis |
||
| Hydroxysteroid 11-beta dehydrogenase 1 |
Hsd11b1 |
10.6 |
| Decidual/trophoblast prolactin-related protein |
Dtprp |
6.2 |
| Hydroxysteroid 11-beta dehydrogenase 2 |
Hsd11b2 |
3.6 |
| Cytochrome P450, 11a |
Cyp11a1 |
2.3 |
| Prostaglandin-endoperoxide synthase 1 |
Ptgs1 |
2.0 |
| Phospholipase inhibition |
||
| Annexin A8 |
Anxa8 |
4.4 |
| Annexin A3 |
Anxa3 |
3.1 |
| Uteroglobin |
Utg |
2.7 |
| Calpactin |
S100a10 |
2.5 |
| Annexin A1 |
Anxa1 |
2.4 |
| Annexin A2 |
Anxa2 |
2.1 |
| Proteolysis and peptidolysis |
||
| Kidney-derived aspartic protease-like protein |
Kdap |
8.2 |
| CTLA-2-beta |
Ctla2b |
8.1 |
| Cathepsin Z |
Ctsz |
3.1 |
| Dipeptidase 1 |
Dpep1 |
3.1 |
| Procollagen C-proteinase enhancer protein |
Pcolce |
2.6 |
| Lipocalin 7 |
Lcn7 |
2.6 |
| Serine-type endopeptidases |
||
| Granzyme G |
Gzmg |
71.4 |
| Granzyme D |
Gzmd |
45.7 |
| Granzyme F |
Gzmf |
40.2 |
| Granzyme E |
Gzme |
19.8 |
| Granzyme C |
Gzmc |
10.7 |
| RIKEN cDNA 2210021K23 gene |
2210021K23Rik |
2.9 |
| Cathepsin G |
Ctsg |
2.2 |
| Protease, serine, 11 (Igf binding) |
Prss11 |
2.2 |
| Granzyme B |
Gzmb |
2.1 |
| Protease inhibitors |
||
| Tissue factor pathway inhibitor 2 |
Tfpi2 |
4.2 |
| Serine protease inhibitor 14 |
Serpinb9e |
3.3 |
| Plasma protease C1 inhibitor |
Serping1 |
2.7 |
| Extracellular matrix remodeling and cell growth |
||
| Regulation of cell growth |
||
| Insulin-like growth factor binding protein 2 |
Igfbp2 |
12.4 |
| Interleukin 1 receptor, type II |
Il1r2 |
5.0 |
| Glucocorticoid-induced leucine zipper |
Gilz |
3.8 |
| Tumor necrosis factor, alpha-induced protein 2 |
Tnfaip2 |
3.3 |
| c-Fos induced growth factor |
Figf |
3.2 |
| Related RAS viral (r-ras) oncogene homolog 2 |
Rras2 |
3.0 |
| Cysteine rich protein 2 |
Crip2 |
2.9 |
| MORF-related gene X |
Morf4l2 |
2.6 |
| Epithelial membrane protein 1 |
Emp1 |
2.5 |
| Four and a half LIM domains 1 |
Fhl1 |
2.3 |
| S100 calcium binding protein A6 (calcyclin) |
S100a6 |
2.3 |
| Insulin-like growth factor binding protein 6 |
Igfbp6 |
2.1 |
| Transforming growth factor, beta 2 |
Tgfb2 |
2.0 |
| Integrin-mediated signaling pathway |
||
| Secreted phosphoprotein 1 |
Spp1 |
17.3 |
| Connective tissue growth factor |
Ctgf |
2.8 |
| Caveolin, caveolae protein |
Cav |
2.5 |
| Ras homolog gene family, member A2 |
Arha |
2.4 |
| Structural constituent of cytoskeleton |
||
| Gelsolin |
Gsn |
2.4 |
| Tropomyosin 4 |
Tpm4 |
3.1 |
| Tubulin, beta 2 |
Tubb2 |
2.2 |
| Extracellular matrix structural constituent |
||
| Microfibrillar associated protein 5 |
Mfap5-pending |
6.9 |
| Elastin |
Eln |
3.1 |
| Procollagen, type XI, alpha 1 |
Col11a1 |
3.0 |
| Fibromodulin |
Fmod |
2.4 |
| Fibrillin 1 |
Fbn1 |
2.3 |
| Procollagen, type V, alpha 2 |
Col5a2 |
2.2 |
| Laminin, gamma 1 |
Lamc1 |
2.2 |
| Procollagen, type I, alpha 2 |
Col1a2 |
2.2 |
| G-protein signaling |
||
| Guanylate cyclase activator 2b |
Guca2b |
15.2 |
| Chemokine orphan receptor 1 |
Cmkor1 |
5.0 |
| Adrenomedullin |
Adm |
2.0 |
| Guanine nucleotide binding protein, gamma 11 |
Gng11 |
2.0 |
| Transcriptional regulation |
||
| Secreted frizzled-related sequence protein 4 |
Sfrp4 |
4.2 |
| Kruppel-like factor 4 |
Klf4 |
3.0 |
| C/EBP delta |
Cebpd |
2.3 |
| Inhibitor of DNA binding 1 |
Idb1 |
2.1 |
| X-box binding protein 1 |
Xbp1 |
2.0 |
| Kruppel-like factor 2 |
Klf2 |
2.0 |
|
Only upregulated genes with a relative fold-change of 2 or more versus non-pregnant mice at 14.5 days gestation and linked to biological categories highlighted by the expression analysis are shown. Full gene lists can be obtained online (see Additional data file 6). | ||
Salomonis et al. Genome Biology 2005 6:R12 doi:10.1186/gb-2005-6-2-r12 |
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