DEG detection sensitivity and specificity as a function of spiked-in fold change level. (a, b)ROC curves using the composite statistic, and different definitions of the true-positive probe sets (criteria given in the legends; FC, spiked-in fold change). The true negatives remain the same for all curves (the probe sets which were not spiked in, or were spiked in at 1x).
Choe et al. Genome Biology 2005 6:R16 doi:10.1186/gb-2005-6-2-r16