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Connecting the dots in Huntington's disease with protein interaction networks

Flaviano Giorgini1 and Paul J Muchowski12*

Author Affiliations

1 Department of Pharmacology, University of Washington, Seattle, WA 98195, USA

2 The Center for Neurogenetics and Neurotherapeutics, University of Washington, Seattle, WA 98195, USA

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Genome Biology 2005, 6:210  doi:10.1186/gb-2005-6-3-210

Published: 28 February 2005

Abstract

Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.