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New evolutionary frontiers from unusual virus genomes

Christopher Desjardins, Jonathan A Eisen email and Vishvanath Nene email

The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20854, USA

author email corresponding author email

Genome Biology 2005, 6:212doi:10.1186/gb-2005-6-3-212

Published: 2 March 2005

Subject areas: Virology, Genome studies, Evolution, Ecology

Abstract

The sequences of two giant viral genomes, Mimivirus and a polydnavirus, have recently been published. Mimivirus has the largest known viral genome and encodes an unprecedented number of proteins, whereas the polydnavirus genome has an extremely low coding density and does not encode DNA-replication proteins. These and other unusual features challenge the way we view the evolution and definition of viruses.


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