Table 3

Ranking of the codon pairs that display the highest residual difference between S. cerevisiae, S. pombe and C. albicans

S. pombe-S. cerevisiae
S. pombe-C. albicans
C. albicans-S. cerevisiae

Context
Difference
Context
Difference
Context
Difference

CAG → CAG
27,798
CAA → CAA
100,639
CAA → CAA
79,38
UUG → AAA
25,266
AAC → AAC
76,716
AAC → AAC
62,939
CUU → CGU
25,168
ACC → ACC
60,208
ACC → ACC
50,735
CAA → CAG
24,507
CCA → CCA
47,603
CCA → CCA
39,196
AAA → AAG
23,593
ACA → ACA
47,359
CAC → CAC
39,032
UUC → AAA
22,86
CAC → CAC
47,175
ACA → ACA
39,029
AAU → AAU
22,021
GGA → AAA
45,043
GGU → GGU
36,501
CAA → CAA
21,259
AAG → AAA
43,994
GGA → UUA
35,81
GUU → CUU
21,194
CAA → CAG
43,927
GGA → AAA
29,786
GAU → GAC
19,483
UCA → UCA
41,533
GUU → GAU
29,753

Anaconda was used to analyze the codon context of the complete genomes of S. cerevisiae, S. pombe and C. albicans. The adjusted residuals of each codon context calculated for each pair of genomes - that is, S. pombe-S. cerevisiae; S. pombe-C. albicans; and C. albicans-S. cerevisiae - were subtracted and the result converted into a positive number by a module calculation. These values were used to rank the respective codon contexts and the 10 highest cases obtained were selected. Among these three yeast species, S. pombe and S. cerevisiae display the lowest differences, with the maximum value of the difference being found for the CAG-CAG pair (27.798). For S. pombe and C. albicans that value reaches 100.639 for the CAA-CAA codon pair. It is noteworthy that the highest difference value for the former pair is lower than the lowest value for the latter in this ranking of context differences. The only codon pair shared between all three yeast pairs is shown in bold.

Moura et al. Genome Biology 2005 6:R28   doi:10.1186/gb-2005-6-3-r28

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