Genome Biology
Volume 6
Issue 4 |
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MinireviewGenomic studies of mood disorders - the brain as a muscle?Alexander B Niculescu  Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA  author email corresponding author email
Genome Biology 2005,
6:215doi:10.1186/gb-2005-6-4-215
Subject areas: Neurobiology, Genome studies, Evolution Abstract
Recent genomic studies showing abnormalities in the fibroblast growth factor system in the postmortem brains of people with major depressive disorder support previous indications of a role for growth factors in mood disorders. Similar molecular pathways, volumetric changes, and the effects of exercise on mood suggest a superficial analogy, and perhaps a deeper relationship, between muscle and brain functioning. | 
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