Genome Biology
Volume 6
Issue 4 |
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MinireviewSINEs point to abundant editing in the human genomeJoshua DeCerbo and Gordon G Carmichael  Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030-3301, USA  author email corresponding author email
Genome Biology 2005,
6:216doi:10.1186/gb-2005-6-4-216
Subject areas: Genome studies, Bioinformatics, Genetics, Molecular biology Abstract
Recent bioinformatic analyses suggest that almost all human transcripts are edited by adenosine deaminases (ADARs), converting adenosines to inosines. Most of this editing is in Alu element transcripts, which are unique to primates. This editing might have no function or might be involved in functions such as the regulation of splicing, chromatin or nuclear localization of transcripts. | 
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