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Derivation of genetic interaction networks from quantitative phenotype data

Becky L Drees, Vesteinn Thorsson, Gregory W Carter, Alexander W Rives, Marisa Z Raymond, Iliana Avila-Campillo, Paul Shannon and Timothy Galitski*

Author Affiliations

Institute for Systems Biology, 1441 N. 34th Street, Seattle, WA 98103, USA

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Genome Biology 2005, 6:R38  doi:10.1186/gb-2005-6-4-r38

Published: 31 March 2005

Abstract

We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.