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Derivation of genetic interaction networks from quantitative phenotype data

Becky L Drees, Vesteinn Thorsson, Gregory W Carter, Alexander W Rives, Marisa Z Raymond, Iliana Avila-Campillo, Paul Shannon and Timothy Galitski*

Author Affiliations

Institute for Systems Biology, 1441 N. 34th Street, Seattle, WA 98103, USA

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Genome Biology 2005, 6:R38  doi:10.1186/gb-2005-6-4-r38

Published: 31 March 2005

Additional files

Additional File 1:

A table showing 75 genetic-interaction inequalities in nine modes of genetic interaction. As described in Materials and methods, all 75 possible phenotype inequalities were classified into nine modes of genetic interaction. The results are listed here.

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Open Data

Additional File 2:

Gene perturbations used in this study. This file lists all genes, mutant alleles, and allele forms (for example, null, gain-of-function, etc.)

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Open Data

Additional File 3:

Phenotype error values in the entire dataset. This plot shows the phenotype error values (Materials and methods) plotted against percentile of all genotypes ordered by error magnitude.

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Open Data

Additional File 4:

Entire genetic interaction network derived from yeast invasion-phenotype data. Figure 1c shows a small part of the genetic-interaction network. This file contains an image including all tested interactions.

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Additional File 5:

Phenotype data for all tested interactions. This file lists all tested genetic interactions as well as the phenotype and error values for all genotypes, WT, A, B, and AB.

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Open Data

Additional File 6:

Mutual information in genetic-interaction patterns. This file lists the mutual information, and significance, among pairs of genes connected by edges in Figure 4.

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Open Data