Figure 2.

Gene perturbations show specific modes of genetic interaction with biological processes. (a) PBS2 deletion interacts additively with mutations of small-GTPase-mediated signal transduction genes. (b) PHD1 overexpression is hypostatic to deletions of invasive-growth genes. (c) ISW1 deletion suppresses the effects of perturbations of small-GTPase-mediated signal transduction genes. Key to interactions as in Figure 1d