Histone modifications: from genome-wide maps to functional insights
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Corresponding authors: Fred van Leeuwen fred.v.leeuwen@nki.nl - Bas van Steensel b.v.steensel@nki.nl
Netherlands Cancer Institute, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands
Genome Biology 2005, 6:113 doi:10.1186/gb-2005-6-6-113
Published: 31 May 2005Abstract
A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.