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Opinion

Histone modifications: from genome-wide maps to functional insights

Fred van Leeuwen and Bas van Steensel

Author Affiliations

Netherlands Cancer Institute, Plesmanlaan 121,1066 CX Amsterdam, The Netherlands

Genome Biology 2005, 6:113  doi:10.1186/gb-2005-6-6-113

Published: 31 May 2005

Abstract

A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome-wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.