Protein family review

The B7 family of immune-regulatory ligands

Mary Collins1*, Vincent Ling2 and Beatriz M Carreno1

Author Affiliations

1 Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA

2 Compound Therapeutics, 1365 Main Street, Waltham, MA 02451, USA

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Genome Biology 2005, 6:223 doi:10.1186/gb-2005-6-6-223

Published: 31 May 2005

The B7 family consists of structurally related, cell-surface protein ligands, which bind to the CD28 family of receptors on lymphocytes and regulate immune responses via 'costimulatory' or 'coinhibitory' signals.