Table 1 |
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|
Fitness of mutants with deletions in flexible central metabolic reactions |
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| Physiological fitness* |
Competitive fitness† |
Physiological fitness |
Competitive fitness |
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|
|
|
|
|
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| Mutants |
MM |
YPD |
YPD |
Mutants |
MM |
YPD |
YPD |
|
|
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| Reference strain |
1 |
1 |
1 |
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| adh1/YOL086C |
0.47 |
0.57 |
0.79 |
mdh2/YOL126C |
0.89 |
0.98 |
1.01 |
| adh3/YMR083W |
0.92 |
0.87 |
0.98 |
mdh3/YDL078C |
1.00 |
0.96 |
1.01 |
| ald5/YER073W |
1.02 |
0.94 |
1 |
mls1/YNL117W |
1 |
0.98 |
1 |
| ald6/YPL061W |
0.34 |
0.87 |
0.9 |
oac1/YKL120W |
0.71 |
0.94 |
1.01 |
| cox5A/YNL052W |
0.63 |
0.91 |
1 |
pck1/YKR097W |
1 |
0.96 |
1 |
| ctp1/YBR291C |
0.91 |
1 |
0.97 |
pda1/YER178W |
0.41 |
0.98 |
1 |
| dal7/YIR031C |
0.94 |
0.85 |
1 |
pgm1/YKL127W |
0.82 |
0.94 |
1 |
| fum1/YPL262W |
0.52 |
0.62 |
0.93 |
pgm2/YMR105C |
0.90 |
1 |
1 |
| gnd1/YHR183W |
0 |
0.87 |
1.01 |
rpe1/YJL121C |
0.33 |
0.94 |
0.88 |
| gnd2/YGR256W |
0.83 |
0.98 |
1 |
sdh1/YKL148C |
0.72 |
0.94 |
1 |
| gcv2/YMR189W |
0.92 |
0.94 |
1 |
ser33/YIL074C |
0.92 |
0.94 |
1.01 |
| gly1/YEL046C |
0.79 |
0.74 |
0.87 |
sfc1/YJR095W |
0.84 |
0.96 |
1.01 |
| gpd1/YDL022W |
1 |
0.98 |
0.84 |
sol1/YNR034W |
0.91 |
1 |
1.02 |
| icl1/YER065C |
1 |
1 |
1 |
sol2/YCRX13W |
0.99 |
0.98 |
1 |
| idp1/YDL066W |
0.92 |
0.94 |
1.03 |
sol3/ YHR163W |
0.71 |
0.94 |
1 |
| idp2/YLR174W |
0.86 |
0.96 |
0.95 |
sol4/ YGR248W |
0.95 |
0.91 |
1.01 |
| lsc1/YOR142W |
1.05 |
0.93 |
1 |
tal1/ YLR354C |
0.89 |
0.94 |
1 |
| mae1/YKL029C |
1.01 |
0.96 |
1 |
YGR043C |
0.92 |
0.87 |
1.02 |
| mdh1/YKL085W |
0.72 |
0.91 |
1 |
zwf1/YNL241C |
0.38 |
0.96 |
ND |
|
|
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|
*Physiological fitness is defined as the maximal specific growth rate of a mutant normalized to the reference strain CEN.PK 113-7D ho::kanMX4. The average from triplicate experiments is shown. The standard deviation was generally below 0.05. †From Steinmetz et al. [20]. ND, not detected. |
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|
Blank et al. Genome Biology 2005 6:R49 doi:10.1186/gb-2005-6-6-r49 |
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