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Opinion

Conservation anchors in the vertebrate genome

Ronny Aloni and Doron Lancet*

Author Affiliations

Department of Molecular Genetics and the Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel

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Genome Biology 2005, 6:115  doi:10.1186/gb-2005-6-7-115

Published: 29 June 2005

Abstract

Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs (ancestral non-coding conserved regions). The frequency of individual ANCORs within the genome, along with their (correlated) inter-species identity scores, helps in assessing the probability that they function in transcription regulation or RNA coding.