Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins
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* Corresponding author: Shiri Freilich shirigo@ebi.ac.uk
Genome Biology 2005, 6:R56 doi:10.1186/gb-2005-6-7-r56
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Method
SpeCond: a method to detect condition-specific gene expression Florence MG Cavalli, Richard Bourgon, Wolfgang Huber, Juan M Vaquerizas, Nicholas M Luscombe Genome Biology 2011, 12:R101 (18 October 2011) A method to detect condition-specific gene expression from microarray data
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Research article
Metabolic innovations towards the human lineage Shiri Freilich, Leon Goldovsky, Christos A Ouzounis, Janet M Thornton BMC Evolutionary Biology 2008, 8:247 (9 September 2008) |
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Research article
How many human genes can be defined as housekeeping with current expression data? Jiang Zhu, Fuhong He, Shuhui Song, Jing Wang, Jun Yu BMC Genomics 2008, 9:172 (16 April 2008) |
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Research
Functional protein divergence in the evolution of Homo sapiens Nuria Lopez-Bigas, Subhajyoti De, Sarah A Teichmann Genome Biology 2008, 9:R33 (15 February 2008) Quantification of the divergence of proteins by functional category shows that morphological changes in metazoa have been driven by variation in regulatory genes. |
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Research
Housekeeping genes tend to show reduced upstream sequence conservation Domènec Farré, Nicolás Bellora, Loris Mularoni, Xavier Messeguer, M Mar Albà Genome Biology 2007, 8:R140 (13 July 2007) Mammalian housekeeping genes show significantly lower promoter sequence conservation, especially upstream of position -500 with respect to the transcription start site, than genes expressed in a subset of tissues. |
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Research
Shiri Freilich, Tim Massingham, Eric Blanc, Leon Goldovsky, Janet M Thornton Genome Biology 2006, 7:R89 (9 October 2006) An analysis of the relationship between duplication events, the time they took place and the expression breadth of the duplicated genes supports the subfunctionalization model, in which expression divergence following gene duplication promotes the retention of a gene in multicellular species. |