Table 2

Top-ranking knock-out experiments proposed for model discrimination

Gene

Function

Score

Downstream genes

Rank

Model


HHF1

Histone

52.1429

74

1

2

SOK2*

Regulator for meiosis and PKA pathway

45.0279

64

2

1

CKA1

Protein kinase of cell cycle

45.0075

64

3

5

A2

Mating response

40.9023

58

4

4

YAP6*

Stress response regulator

35.1652

50

5

1, 3

NRG1

Regulator of glucose dependent genes

31.6501

45

6

3

FKH1

Regulator of cell cycle

29.1194

41

7

2

FKH2

Regulator of cell cycle

26.7131

38

8

7

SLT2

Protein kinase of cell wall integrity pathway

23.4727

31

9

8

MSN4*

Regulator of stress response

21.8224

31

10

1

HAP4*

Regulator of cellular respiration

6.3310

9

34

1


Each proposed target gene is reported, along with its function, mutual information score, rank, and the model(s) it informs. All target genes are non-lethal in rich media. *Gene knockouts selected in this study.

Yeang et al. Genome Biology 2005 6:R62   doi:10.1186/gb-2005-6-7-r62

Open Data