Table 2 |
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|
Top-ranking knock-out experiments proposed for model discrimination |
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| Gene |
Function |
Score |
Downstream genes |
Rank |
Model |
|
|
|||||
| HHF1 |
Histone |
52.1429 |
74 |
1 |
2 |
| SOK2* |
Regulator for meiosis and PKA pathway |
45.0279 |
64 |
2 |
1 |
| CKA1 |
Protein kinase of cell cycle |
45.0075 |
64 |
3 |
5 |
| A2 |
Mating response |
40.9023 |
58 |
4 |
4 |
| YAP6* |
Stress response regulator |
35.1652 |
50 |
5 |
1, 3 |
| NRG1 |
Regulator of glucose dependent genes |
31.6501 |
45 |
6 |
3 |
| FKH1 |
Regulator of cell cycle |
29.1194 |
41 |
7 |
2 |
| FKH2 |
Regulator of cell cycle |
26.7131 |
38 |
8 |
7 |
| SLT2 |
Protein kinase of cell wall integrity pathway |
23.4727 |
31 |
9 |
8 |
| MSN4* |
Regulator of stress response |
21.8224 |
31 |
10 |
1 |
| HAP4* |
Regulator of cellular respiration |
6.3310 |
9 |
34 |
1 |
|
|
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|
Each proposed target gene is reported, along with its function, mutual information score, rank, and the model(s) it informs. All target genes are non-lethal in rich media. *Gene knockouts selected in this study. |
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|
Yeang et al. Genome Biology 2005 6:R62 doi:10.1186/gb-2005-6-7-r62 |
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