Highly Accessed Review

The SET-domain protein superfamily: protein lysine methyltransferases

Shane C Dillon1*, Xing Zhang2, Raymond C Trievel3 and Xiaodong Cheng2

Author Affiliations

1 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

2 Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA

3 Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA

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Genome Biology 2005, 6:227 doi:10.1186/gb-2005-6-8-227

Published: 2 August 2005

Abstract

The SET-domain protein methyltransferase superfamily includes all but one of the proteins known to methylate histones on lysine. Histone methylation is important in the regulation of chromatin and gene expression.