Genome Biology
Volume 6
Issue 8 |
Viewing options:Associated material:Related literature:- Articles citing this article
- Other articles by authors
- Related articles/pages
Tools:Post to:
|
MinireviewCytological profiling: providing more haystacks for chemists' needlesJanet Lorang and Randall W King  Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA  author email corresponding author email
Genome Biology 2005,
6:228doi:10.1186/gb-2005-6-8-228
Subject areas: Drug discovery, Biochemistry and structural biology, Bioinformatics, Molecular biology Abstract
Conventional high-throughput 'chemical genetic' screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by affinity purification to identify targets of compounds with interesting effects, can lead to the identification of novel inhibitors. | 
on Google Scholar
