Minireview
Cytological profiling: providing more haystacks for chemists' needles
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* Corresponding author: Randall W King randy_king@hms.harvard.edu
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Genome Biology 2005, 6:228 doi:10.1186/gb-2005-6-8-228
Published: 29 July 2005Abstract
Conventional high-throughput 'chemical genetic' screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by affinity purification to identify targets of compounds with interesting effects, can lead to the identification of novel inhibitors.