Genome Biology

official impact factor 6.89

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Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content

Penelope R Haddrill*, Brian Charlesworth, Daniel L Halligan and Peter Andolfatto

Genome Biology 2005, 6:R67 doi:10.1186/gb-2005-6-8-r67

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BioMed Central: 12 citations

Research   Open Access

Selection for the compactness of highly expressed genes in Gallus gallus

You S Rao, Zhang F Wang, Xue W Chai, Guo Z Wu, Ming Zhou, Qing H Nie, Xi Q Zhang Biology Direct 2010, 5:35 (14 May 2010)

Research article   Open Access Highly Accessed

Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3

Nikolai P Kandul, Mohamed AF Noor BMC Genetics 2009, 10:67 (19 October 2009)

Large introns in the Drosophila Bru-3 gene promote both alternative splicing by exon skipping and exon turnover during evolution, suggesting that large introns could be a reservoir of genetic diversity.

Research article   Open Access Highly Accessed

Patterns of exon-intron architecture variation of genes in eukaryotic genomes

Liucun Zhu, Ying Zhang, Wen Zhang, Sihai Yang, Jian-Qun Chen, Dacheng Tian BMC Genomics 2009, 10:47 (24 January 2009)

Research article   Open Access

Evidence against the energetic cost hypothesis for the short introns in highly expressed genes

Yi-Fei Huang, Deng-Ke Niu BMC Evolutionary Biology 2008, 8:154 (20 May 2008)

Research article   Open Access

Patterns of selective constraints in noncoding DNA of rice

Xingyi Guo, Yu Wang, Peter D Keightley, Longjiang Fan BMC Evolutionary Biology 2007, 7:208 (1 November 2007)

Research   Open Access Highly Accessed

Large-scale analysis of transcriptional cis-regulatory modules reveals both common features and distinct subclasses

Long Li, Qianqian Zhu, Xin He, Saurabh Sinha, Marc S Halfon Genome Biology 2007, 8:R101 (5 June 2007)

Analysis of 280 experimentally-verified cis-regulatory modules from Drosophila reveal features both common to all and unique to distinct subclasses of modules.

Research   Open Access Highly Accessed

Patterns and rates of intron divergence between humans and chimpanzees

Elodie Gazave, Tomàs Marqués-Bonet, Olga Fernando, Brian Charlesworth, Arcadi Navarro Genome Biology 2007, 8:R21 (19 February 2007)

An analysis of human-chimpanzee intron divergence shows strong correlations between intron length and divergence and GC-content.

Research   Open Access

Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over

Penelope R Haddrill, Daniel L Halligan, Dimitris Tomaras, Brian Charlesworth Genome Biology 2007, 8:R18 (6 February 2007)

Observations from a genome-wide comparison of Drosophila melanogaster and Drosophila yakuba are consistent with a severe reduction in the efficacy of selection in the absence of crossing over, resulting in the accumulation of deleterious mutations in these regions.

Research article   Open Access

Compensatory relationship between splice sites and exonic splicing signals depending on the length of vertebrate introns

Colin N Dewey, Igor B Rogozin, Eugene V Koonin BMC Genomics 2006, 7:311 (8 December 2006)

Research   Open Access

Fine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura

Stuart J Macdonald, Anthony D Long Genome Biology 2006, 7:R67 (27 July 2006)

Comparative genomics reveals fine-scale structural variants, including microinversions, distinguishing two diverged Drosophila species

Methodology article   Open Access

MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution

Jun Wang, Peter D Keightley, Toby Johnson BMC Bioinformatics 2006, 7:292 (8 June 2006)

Methodology article   Open Access

Development and application of three-tiered nuclear genetic markers for basal Hexapods using single-stranded conformation polymorphism coupled with targeted DNA sequencing

Ryan C Garrick, Paul Sunnucks BMC Genetics 2006, 7:11 (22 February 2006)

An improved technique enables cloning-free genotyping of polymorphisms for population studies, in invertebrates such as the Australian Collembola, based on single-stranded conformation polymorphism followed by genotyping and target-DNA sequencing.