Method
Genome-wide promoter extraction and analysis in human, mouse, and rat
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* Corresponding author: Michael Q Zhang mzhang@cshl.edu
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Genome Biology 2005, 6:R72 doi:10.1186/gb-2005-6-8-r72
Published: 1 August 2005Abstract
Large-scale and high-throughput genomics research needs reliable and comprehensive genome-wide promoter annotation resources. We have conducted a systematic investigation on how to improve mammalian promoter prediction by incorporating both transcript and conservation information. This enabled us to build a better multispecies promoter annotation pipeline and hence to create CSHLmpd (Cold Spring Harbor Laboratory Mammalian Promoter Database) for the biomedical research community, which can act as a starting reference system for more refined functional annotations.