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Review

Phosphoproteomics: new insights into cellular signaling

Marc Mumby* and Deirdre Brekken

Author Affiliations

Department of Pharmacology and the Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA

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Genome Biology 2005, 6:230  doi:10.1186/gb-2005-6-9-230

Published: 17 August 2005

Abstract

Developments in the field of phosphoproteomics have been fueled by the need simultaneously to monitor many different phosphoproteins within the signaling networks that coordinate responses to changes in the cellular environment. This article presents a brief review of phosphoproteomics with an emphasis on the biological insights that have been derived so far.