Figure 1.

Stability of mRNA secondary structures for 'Sh.4-fold' simulants relative to real transcripts. Histogram of Z-scores for ΔG, the number of standard deviations the real mRNA is away from the mean stability of the simulants, following randomizations shuffling nucleotides at 4-fold degenerate sites (1,000 randomizations per gene, N = 70). The line shows the null normal distribution.