Genome Biology
Volume 6
Issue 9 |
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 MethodA computational method to predict genetically encoded rare amino acids in proteinsBarnali N Chaudhuri  and Todd O Yeates  UCLA-DOE Institute for Genomics and Proteomics and Department of Chemistry and Biochemistry, University of California, Los Angeles, USA  author email corresponding author email
Genome Biology 2005,
6:R79doi:10.1186/gb-2005-6-9-r79
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| Published: |
31 August 2005 |
Subject areas: Bioinformatics, Microbiology and parasitology, Biochemistry and structural biology, Molecular biology Abstract
In several natural settings, the standard genetic code is expanded to incorporate two additional amino acids with distinct functionality, selenocysteine and pyrrolysine. These rare amino acids can be overlooked inadvertently, however, as they arise by recoding at certain stop codons. We report a method for such recoding prediction from genomic data, using read-through similarity evaluation. A survey across a set of microbial genomes identifies almost all the known cases as well as a number of novel candidate proteins. | 
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