Figure 1.

L2L and the L2L microarray database. (a) The centerpiece of L2L is the L2L Microarray Database, a collection of published microarray data in the form of lists of genes that are up- or downregulated in some condition. The L2L Microarray Analysis Tool (MAT) is a program that compares those lists with a user's microarray data, and reports statistically significant overlaps. The analysis tool includes a web browser interface, but the L2L application itself can be downloaded and run directly from the command line for batch or customized analyses. Three additional sets of lists, based on the three organizing principles of Gene Ontology, can also be used with the analysis tool. (b) The L2L Microarray Database contains over 350 lists compiled from over 100 selected microarray publications. A wide variety of topics are represented, from chromatin modifications and DNA damage to the immune response and adipocyte differentiation.