|
Host drug targets that have antiviral activity |
||||||
| Virus family |
Virus species |
Host-cell target |
Drug |
Antiviral activity in vitro |
Antiviral activity in vivo |
References |
|
|
||||||
| Poxviridae |
Vaccinia virus |
Abl tyrosine kinase |
Gleevec |
+ |
+ |
[13] |
| Herpesviridae |
KSHV |
c-Kit |
Gleevec |
+ |
+ |
[14,21] |
| KSHV |
Vitamin D receptor |
Vitamin D analog EB1089 |
+ |
- |
[16] |
|
| HSV-1 |
EIF-2α |
Salubrinal |
+ |
- |
[30] |
|
| HCMV |
COX-2 |
BMS-279652 |
+ |
- |
[15,23] |
|
| BMS-279654 |
||||||
| BMS-279655 |
||||||
| Indomethacin |
||||||
| Aspirin |
||||||
| Unclassified |
Hepatitis D virus |
Farnesyltransferase |
FTI-277 |
+ |
+ |
[18,19] |
| FTI-2153 |
||||||
| Hepadnaviridae |
Hepatitis B virus |
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) |
siRNA |
+ |
- |
[31] |
| Retroviridae |
HIV |
HMG-CoA reductase |
Lovastatin |
+ |
+ |
[17] |
| HIV |
Geranylgeranyltransferase I |
GGTI-286 |
+ |
- |
[17] |
|
| HIV |
ATM kinase |
KU-55933 |
+ |
- |
[28] |
|
| HIV |
Deoxyhypusine synthase |
CNI-1493 |
+ |
- |
[29] |
|
| HIV |
Histone deacetylase |
Valporic acid |
+ |
+ |
[32,33] |
|
| Flaviviridae |
West Nile disease virus |
c-Yes (Src family kinases) |
PP2 SU6656 |
+ |
- |
[20] |
Kellam Genome Biology 2006 7:201 doi:10.1186/gb-2006-7-1-201 |
||||||