Leaner and meaner genomes in Escherichia coli
Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Genome Biology 2006, 7:237 doi:10.1186/gb-2006-7-10-237Published: 24 October 2006
A 'better' Escherichia coli K-12 genome has recently been engineered in which about 15% of the genome has been removed by planned deletions. Comparison with related bacterial genomes that have undergone a natural reduction in size suggests that there is plenty of scope for yet more deletions.