Figure 1.

(a) For each of 10 random partitions of training cohorts into training and test sets we rank the genes according to their average Cox-scores over the Ntrain training cohorts (Ntrain = 3). (b) 1, Definition of MPI and evaluation of the optimal classifier(s) using the independent test sets of the training cohorts. 2,

<a onClick="popup('http://genomebiology.com/2006/7/10/R101/mathml/M1','MathML',630,470);return false;" target="_blank" href="http://genomebiology.com/2006/7/10/R101/mathml/M1">View MathML</a>

denotes the D-index of the top n-gene classifier for partition/realization p in test set of the training cohort s. 3,

<a onClick="popup('http://genomebiology.com/2006/7/10/R101/mathml/M2','MathML',630,470);return false;" target="_blank" href="http://genomebiology.com/2006/7/10/R101/mathml/M2">View MathML</a>

denotes the weighted average D-index over the test sets in the training cohorts where Ns denotes the size of the test set of training cohort s. 4, The optimal classifier for each partition/realization p,

<a onClick="popup('http://genomebiology.com/2006/7/10/R101/mathml/M3','MathML',630,470);return false;" target="_blank" href="http://genomebiology.com/2006/7/10/R101/mathml/M3">View MathML</a>

, is defined by the number of top-ranked genes, n, that maximizes

<a onClick="popup('http://genomebiology.com/2006/7/10/R101/mathml/M2','MathML',630,470);return false;" target="_blank" href="http://genomebiology.com/2006/7/10/R101/mathml/M2">View MathML</a>

. (c) Validation of the optimal classifiers

<a onClick="popup('http://genomebiology.com/2006/7/10/R101/mathml/M3','MathML',630,470);return false;" target="_blank" href="http://genomebiology.com/2006/7/10/R101/mathml/M3">View MathML</a>

in completely independent external cohorts.

Teschendorff et al. Genome Biology 2006 7:R101   doi:10.1186/gb-2006-7-10-r101
Download authors' original image