Additional data file 4.
The D-index (and associated 68% CI) of prognostic separation for the hybrid prognostic index (HPI ~ SPI + MPI*; red) in the three external cohorts (A1) JRH-1, (B1) UPP and (C1) JRH-2. In all cases, the risk-ordering of samples by the HPI is determined by the average ranking induced by SPI and MPI*. Also shown is the D-index of the standard prognostic index (BLACK) in each of the three external cohorts. The corresponding log-rank test p values (in log10-space) of the SPI and HPI classifiers are shown for the cohorts (A2) JRH-1, (B2) UPP and (C2) JRH-2. The 0.05 confidence threshold line is indicated (green).
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Teschendorff et al. Genome Biology 2006 7:R101 doi:10.1186/gb-2006-7-10-r101