Table 2 |
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|
The D-index of prognostic factors across cohorts |
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|
Training |
Test |
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|
|
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|
Factor |
NKI2 |
ECM |
NCH |
JRH-1 |
UPP |
JRH-2* |
|
|
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|
Grade |
3.80 (<10-5) |
NA |
3.57 (0.001) |
3.84 (0.003) |
2.55 (0.0003) |
2.15 (0.17) |
|
Node status |
1.01 (0.97) |
all LN- |
2.23 (0.05) |
2.64 (0.04) |
4.03 (<10-6) |
2.36 (0.25) |
|
Size |
1.59 (0.06) |
NA |
3.36 (0.003) |
4.16 (<10-3) |
3.18 (<10-5) |
3.04 (0.008) |
|
NPI |
2.27 (<10-3) |
NA |
4.07 (<10-3) |
5.16 (<10-4) |
3.82 (<10-7) |
3.78 (0.03) |
|
MPI† |
3.32 (<10-3) |
2.29 (0.002) |
NA |
3.20 (0.002) |
2.71 (<10-4) |
7.96 (<10-4) |
|
MPI‡ |
3.64 (<10-7) |
2.56 (<10-6) |
6.45 (<10-5) |
3.44 (<10-3) |
2.80 (<10-4) |
11.26 (<10-5) |
|
MPI§ |
3.64 (<10-6) |
2.51 (<10-5) |
6.51 (<10-5) |
3.10 (<10-5) |
2.84 (0.001) |
10.10 (<10-4) |
|
|
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|
For the classical prognostic factors we give, where available, the D-index and log-rank test p values in the training cohorts NKI2, ECM and NCH, and test cohorts JRH-1, UPP and JRH-2. *For JRH-2 the number of samples with available grade and node status information were only 57 and 38, respectively. †For the MPI we give the median D-index and log-rank test p value over the ten molecular classifiers. The range for the D-index and p values over the 10 classifiers were: 2.27 to 4.35 (0.009 to 1.1 × 10-5) in NKI2; 1.78 to 2.75 (0.024 to 2 × 10-4) in ECM; 2.04 to 3.96 (0.039 to 0.0003) in JRH-1; 2.39 to 3.04 (1.7 × 10-4 to 6.7 × 10-6) in UPP; and 5.08 to 12.61 (8 × 10-4 to 8.4 × 10-6) in JRH-2. ‡The MPI based on the optimal 52-gene classifier. §The MPI based on the 17-gene classifier. NA, not available. |
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|
Teschendorff et al. Genome Biology 2006 7:R101 doi:10.1186/gb-2006-7-10-r101 |
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