Table 3

Top prognostic genes in ER+ breast cancer

UniGene symbol

Coefficient sign

Cytoband

GO


RACGAP1

+

12q13.12

GTPase activator activity, electron transporter activity

STK6

+

20q13.2-q13.3

ATP binding, mitosis, phosphorylation, kinase activity

HUMMLC2B

-

16p11.2

calcium ion binding, muscle myosin

MELK

+

9p13.2

ATP binding, phosphorylation, tyrosine kinase activity

PPARA

-

22q12-q13.1

Transcription factor, steroid hormone activity/lipid metabolism

DHCR7

+

11q13.2-q13.5

cholesterol binding and biosynthesis, electron transporter activity

MAD2L1

+

4q27

Cell-cycle, mitotic checkpoint, spindle

ZWINT

+

10q21-q22

Nucleus

KIF20A

+

5q31

ATP binding, microtubule associated complex

CDCA8

+

1p34.3

Cytokinesis

KIAA0101

+

15q22.31

PCNA associated factor

TIMELESS

+

12q12-q13

Development, negative regulation of transcription

PTTG1

+

5q35.1

DNA metabolism, repair, replication and chromosome cycle

WSB2

+

12q24.23

Intracellular signaling cascade

ABCC5

+

3q27

ATP binding, ATPase activity, transmembrane movement

KIF23

+

15q23

ATP binding, microtubule complex/motor activity, mitosis

H2AFY

+

5q31.3-q32

DNA binding, chromosome organization, nucleosome assembly


Top ranked 17 prognostic genes in ER+ breast cancer as determined by a meta-analysis of three major breast cancer data sets. We give the sign of their global average Cox-regression coefficient ('+' means upregulated in poor outcome tumors; '-' means downregulated in poor outcome tumors), cytoband position and selected abbreviated Gene Ontology.

Teschendorff et al. Genome Biology 2006 7:R101   doi:10.1186/gb-2006-7-10-r101

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