Table 4 |
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|
Multivariate D-index analysis |
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|
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
Opt. |
|
|
|
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|
JRH-1 |
|||||||||||
|
MPI (A) |
0.21 |
0.19 |
0.03 |
0.03 |
0.05 |
0.06 |
0.43 |
0.12 |
0.04 |
0.16 |
0.15 |
|
Grade |
0.06 |
0.07 |
0.11 |
0.05 |
0.10 |
0.11 |
0.05 |
0.08 |
0.10 |
0.10 |
0.05 |
|
Node status |
0.79 |
0.73 |
0.96 |
0.86 |
0.93 |
0.89 |
0.65 |
0.87 |
0.83 |
0.91 |
0.91 |
|
Size |
0.07 |
0.01 |
0.02 |
0.05 |
0.03 |
0.05 |
0.04 |
0.02 |
0.02 |
0.11 |
0.11 |
|
MPI (B) |
0.22 |
0.31 |
0.08 |
0.06 |
0.13 |
0.14 |
0.42 |
0.18 |
0.11 |
0.16 |
0.16 |
|
NPI |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
0.01 |
<0.005 |
<0.005 |
<0.005 |
0.01 |
0.01 |
|
UPP |
|||||||||||
|
MPI (A) |
0.01 |
0.01 |
0.06 |
0.01 |
0.02 |
0.01 |
<0.005 |
0.01 |
0.01 |
0.01 |
0.01 |
|
Grade |
0.72 |
0.84 |
0.85 |
0.90 |
0.98 |
0.99 |
0.73 |
0.83 |
0.85 |
0.88 |
0.83 |
|
Node status |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
|
Size |
0.02 |
0.02 |
0.02 |
0.02 |
0.02 |
0.02 |
0.02 |
0.03 |
0.02 |
0.02 |
0.02 |
|
MPI (B) |
0.02 |
0.03 |
0.12 |
0.02 |
0.04 |
0.03 |
0.01 |
0.02 |
0.02 |
0.02 |
0.02 |
|
NPI |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
0.01 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
<0.005 |
|
JRH-2 |
|||||||||||
|
MPI (A) |
0.01 |
0.01 |
0.01 |
0.01 |
0.02 |
0.01 |
0.01 |
0.04 |
0.01 |
<0.005 |
0.01 |
|
Grade |
0.19 |
0.10 |
0.24 |
0.24 |
0.07 |
0.15 |
0.23 |
0.13 |
0.21 |
0.43 |
0.10 |
|
Node status |
0.44 |
0.16 |
0.76 |
0.45 |
0.24 |
0.35 |
0.67 |
0.50 |
0.25 |
0.37 |
0.24 |
|
Size |
0.12 |
0.73 |
0.28 |
0.28 |
0.93 |
0.82 |
0.27 |
0.47 |
0.35 |
0.36 |
0.97 |
|
MPI (B) |
<0.005 |
<0.005 |
0.01 |
0.01 |
<0.005 |
0.01 |
<0.005 |
0.01 |
<0.005 |
<0.005 |
<0.005 |
|
NPI* |
0.51 |
0.53 |
0.75 |
0.58 |
0.97 |
0.78 |
0.99 |
0.63 |
0.50 |
0.47 |
0.96 |
|
|
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|
Given are the rounded p values (to two significant digits) of the D-indices for two multivariate models, model A is log(h(t)) ~ (Grade) + (NodeStatus) + (TumorSize) + MPIp and model-B is log(h(t)) ~ NPI + MPIp, in the three external cohorts JRH-1, UPP and JRH-2. Columns label the 10 different derived molecular classifiers, depending on the training-test set partition p used, and the optimal 52-gene classifier. *For JRH-2 only 36 samples with NPI information were available. Opt., optimal. |
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|
Teschendorff et al. Genome Biology 2006 7:R101 doi:10.1186/gb-2006-7-10-r101 |
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