Table 5

The prognostic added value of the MPI

Model

JRH-1

UPP

JRH-2^†

Grade

3.85

2.55

2.15

Grade + MPI*

5.85 (2.49-13.72)

2.85 (1.79-4.51)

10.60 (2.79-40.20)

Grade + MPI**

4.62 (2.15-9.91)

2.90 (1.83-4.58)

8.14 (2.11-31.31)

Node Status

2.64

4.03

2.36

Node Status + MPI*

2.98 (1.48-6.01)

4.71 (2.83-7.86)

14.07 (2.08-94.84)

Node Status + MPI**

3.09 (1.53-6.23)

4.40 (2.74-7.06)

11.79 (1.86-74.44)

Size

4.16

3.18

3.04

Size + MPI*

5.40 (2.51-11.62)

3.41 (2.16-5.38)

5.21 (2.29-11.84)

Size + MPI**

4.88 (2.35-10.13)

3.65 (2.29-5.81)

4.51 (2.08-9.77)

NPI

5.16

3.82

3.78

NPI + MPI*

5.85 (2.54-13.47)

4.02 (2.52-6.41)

19.11 (2.62-139.3)

NPI + MPI**

4.93 (2.30-10.56)

4.04 (2.53-6.44)

25.23 (2.53-251.6)

For each standard prognostic index SPI (grade, node status, size and NPI) we compare their D-index with the D-index of the corresponding equal-weight hybrid prognostic model, defined by a hybrid prognostic index HPI, where HPI ~ SPI + MPI* or HPI ~ SPI + MPI** (see Materials and methods). 95% CI for the hybrid prognostic model D-index values are shown in brackets. MPI* denotes the index of the optimal 52-gene classifier. MPI** denotes the index of the 17-gene classifier. ^†For JRH-2 only 36 samples with NPI information were available.

Teschendorff et al. Genome Biology 2006 7:R101   doi:10.1186/gb-2006-7-10-r101